| Identification |
|---|
| HMDB Protein ID
| HMDBP13903 |
| Secondary Accession Numbers
| None |
| Name
| 5-hydroxytryptamine receptor 2A |
| Synonyms
|
- 5-HT-2
- 5-HT-2A
- Serotonin receptor 2A
|
| Gene Name
| HTR2A |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity). |
| Pathways
|
- Calcium signaling pathway
- Gap junction
- Inflammatory mediator regulation of TRP channels
- Neuroactive ligand-receptor interaction
- Serotonergic synapse
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| protein localization to cytoskeleton |
| positive regulation of phosphatidylinositol biosynthetic process |
| phosphatidylinositol 3-kinase signaling |
| activation of phospholipase C activity |
| behavior |
| positive regulation of kinase activity |
| positive regulation of fat cell differentiation |
| positive regulation of ERK1 and ERK2 cascade |
| response to drug |
| positive regulation of glycolysis |
| positive regulation of peptidyl-tyrosine phosphorylation |
| release of sequestered calcium ion into cytosol |
| Cellular Component |
| cytoplasmic vesicle |
| G protein-coupled serotonin receptor complex |
| presynapse |
| caveola |
| dendrite |
| integral to plasma membrane |
| axon |
| Molecular Function |
| serotonin binding |
| 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding |
| Gq/11-coupled serotonin receptor activity |
| identical protein binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 471 |
| Molecular Weight
| 52602.58 |
| Theoretical pI
| 7.662 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 76-99;111-132;149-171;192-215;234-254;325-346;363-384;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P50128 |
| UniProtKB/Swiss-Prot Entry Name
| 5HT2A_MACMU |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Johnson MP, Baez M, Kursar JD, Nelson DL: Species differences in 5-HT2A receptors: cloned pig and rhesus monkey 5-HT2A receptors reveal conserved transmembrane homology to the human rather than rat sequence. Biochim Biophys Acta. 1995 May 24;1236(1):201-6. doi: 10.1016/0005-2736(95)00073-c. [PubMed:7794950 ]
|
