| Identification |
|---|
| HMDB Protein ID
| HMDBP13870 |
| Secondary Accession Numbers
| None |
| Name
| D-alanine--D-alanyl carrier protein ligase |
| Synonyms
|
- DCL
- D-alanine--poly(phosphoribitol) ligase subunit 1
- D-alanine-activating enzyme
- DAE
|
| Gene Name
| DLTA |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. |
| Pathways
|
- Cationic antimicrobial peptide (CAMP) resistance
- D-Amino acid metabolism
- lipoteichoic acid biosynthesis
- Two-component system
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| lipoteichoic acid biosynthetic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| ATP binding |
| D-alanine [D-alanyl carrier protein] ligase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 512 |
| Molecular Weight
| 56998.615 |
| Theoretical pI
| 5.042 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q1J667 |
| UniProtKB/Swiss-Prot Entry Name
| DLTA_STRPF |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Beres SB, Richter EW, Nagiec MJ, Sumby P, Porcella SF, DeLeo FR, Musser JM: Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7059-64. doi: 10.1073/pnas.0510279103. Epub 2006 Apr 24. [PubMed:16636287 ]
|
