| Identification |
|---|
| HMDB Protein ID
| HMDBP13867 |
| Secondary Accession Numbers
| None |
| Name
| D-alanine--D-alanyl carrier protein ligase |
| Synonyms
|
- DCL
- D-alanine--poly(phosphoribitol) ligase subunit 1
- D-alanine-activating enzyme
- DAE
|
| Gene Name
| DLTA |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. |
| Pathways
|
- Cationic antimicrobial peptide (CAMP) resistance
- D-Amino acid metabolism
- lipoteichoic acid biosynthesis
- Two-component system
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| lipoteichoic acid biosynthetic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| ATP binding |
| D-alanine [D-alanyl carrier protein] ligase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 512 |
| Molecular Weight
| 56951.595 |
| Theoretical pI
| 4.962 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| C0MBD6 |
| UniProtKB/Swiss-Prot Entry Name
| DLTA_STRE4 |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Holden MT, Heather Z, Paillot R, Steward KF, Webb K, Ainslie F, Jourdan T, Bason NC, Holroyd NE, Mungall K, Quail MA, Sanders M, Simmonds M, Willey D, Brooks K, Aanensen DM, Spratt BG, Jolley KA, Maiden MC, Kehoe M, Chanter N, Bentley SD, Robinson C, Maskell DJ, Parkhill J, Waller AS: Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens. PLoS Pathog. 2009 Mar;5(3):e1000346. doi: 10.1371/journal.ppat.1000346. Epub 2009 Mar 27. [PubMed:19325880 ]
|
