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Showing Protein Tyrosine-protein kinase Lyn (HMDBP13825)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13825
Secondary Accession Numbers None
Name Tyrosine-protein kinase Lyn
Synonyms
  1. V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
  2. p53Lyn
  3. p56Lyn
Gene Name LYN
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B (By similarity). Phosphorylates LPXN on 'Tyr-72' (By similarity). Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-96'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity).
Pathways
  • B cell receptor signaling pathway
  • Chemokine signaling pathway
  • Epstein-Barr virus infection
  • Fc epsilon RI signaling pathway
  • Fc gamma R-mediated phagocytosis
  • Kaposi sarcoma-associated herpesvirus infection
  • Lipid and atherosclerosis
  • Long-term depression
  • NF-kappa B signaling pathway
  • Platelet activation
  • Viral carcinogenesis
Reactions Not Available
GO Classification
Biological Process
response to drug
innate immune response
cell differentiation
response to organic cyclic compound
regulation of cytokine production
regulation of inflammatory response
positive regulation of cell proliferation
intracellular signal transduction
hemopoiesis
cellular response to retinoic acid
negative regulation of cell proliferation
platelet degranulation
cellular response to extracellular stimulus
response to amino acid stimulus
neuron projection development
response to DNA damage stimulus
response to toxin
response to axon injury
negative regulation of MAP kinase activity
response to peptide hormone stimulus
response to insulin stimulus
B cell receptor signaling pathway
positive regulation of cellular component movement
protein phosphorylation
cellular response to heat
negative regulation of ERK1 and ERK2 cascade
toll-like receptor 4 signaling pathway
positive regulation of cell migration
positive regulation of protein phosphorylation
response to hormone stimulus
erythrocyte differentiation
response to carbohydrate stimulus
positive regulation of phosphorylation
positive regulation of neuron projection development
negative regulation of protein phosphorylation
negative regulation of myeloid leukocyte differentiation
lipopolysaccharide-mediated signaling pathway
regulation of B cell apoptotic process
regulation of cell adhesion mediated by integrin
regulation of B cell receptor signaling pathway
peptidyl-tyrosine phosphorylation
regulation of ERK1 and ERK2 cascade
regulation of mast cell activation
transmembrane receptor protein tyrosine kinase signaling pathway
protein autophosphorylation
negative regulation of B cell proliferation
positive regulation of mast cell proliferation
positive regulation of phosphatidylinositol 3-kinase activity
adaptive immune response
negative regulation of toll-like receptor 2 signaling pathway
positive regulation of glial cell proliferation
negative regulation of toll-like receptor 4 signaling pathway
regulation of platelet aggregation
B cell homeostasis
dendritic cell differentiation
Fc receptor mediated inhibitory signaling pathway
Fc receptor mediated stimulatory signaling pathway
histamine secretion by mast cell
immune response-regulating cell surface receptor signaling pathway
negative regulation of intracellular signal transduction
negative regulation of mast cell proliferation
oligodendrocyte development
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
positive regulation of dendritic cell apoptotic process
positive regulation of Fc receptor mediated stimulatory signaling pathway
positive regulation of oligodendrocyte progenitor proliferation
positive regulation of stress-activated protein kinase signaling cascade
positive regulation of tyrosine phosphorylation of STAT protein
regulation of erythrocyte differentiation
regulation of mast cell degranulation
regulation of monocyte chemotaxis
regulation of release of sequestered calcium ion into cytosol
response to sterol depletion
tolerance induction to self antigen
Cellular Component
mitochondrial intermembrane space
mitochondrial membrane
cytoplasm
plasma membrane
nucleus
membrane
membrane raft
Golgi apparatus
perinuclear region of cytoplasm
mitochondrial crista
postsynaptic density
adherens junction
extrinsic to internal side of plasma membrane
protein-containing complex
glutamatergic synapse
integrin alpha2-beta1 complex
postsynaptic specialization, intracellular component
Molecular Function
ATP binding
receptor binding
protein kinase activity
enzyme binding
kinase activity
SH3 domain binding
platelet-derived growth factor receptor binding
protein-containing complex binding
transmembrane receptor protein tyrosine kinase activity
protein tyrosine kinase activity
ion channel binding
integrin binding
ubiquitin protein ligase binding
non-membrane spanning protein tyrosine kinase activity
ephrin receptor binding
phosphoprotein binding
gamma-tubulin binding
glycosphingolipid binding
phosphorylation-dependent protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 512
Molecular Weight 58659.605
Theoretical pI 7.111
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q07014
UniProtKB/Swiss-Prot Entry Name LYN_RAT
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Rider LG, Raben N, Miller L, Jelsema C: The cDNAs encoding two forms of the LYN protein tyrosine kinase are expressed in rat mast cells and human myeloid cells. Gene. 1994 Jan 28;138(1-2):219-22. [PubMed:8125304 ]
  2. Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871. [PubMed:22673903 ]
  3. Vonakis BM, Chen H, Haleem-Smith H, Metzger H: The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE. J Biol Chem. 1997 Sep 19;272(38):24072-80. doi: 10.1074/jbc.272.38.24072. [PubMed:9295361 ]
  4. Donella-Deana A, Cesaro L, Ruzzene M, Brunati AM, Marin O, Pinna LA: Spontaneous autophosphorylation of Lyn tyrosine kinase at both its activation segment and C-terminal tail confers altered substrate specificity. Biochemistry. 1998 Feb 3;37(5):1438-46. doi: 10.1021/bi971332s. [PubMed:9477973 ]