| Identification |
|---|
| HMDB Protein ID
| HMDBP13815 |
| Secondary Accession Numbers
| None |
| Name
| Lipid A biosynthesis myristoyltransferase 2 |
| Synonyms
|
- Kdo(2)-lauroyl-lipid IV(A) myristoyltransferase 2
|
| Gene Name
| LPXM2 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A. Can probably also catalyze the transfer of myristate to Kdo(2)-(palmitoleoyl)-lipid IV(A) to form the cold-adapted Kdo(2)-lipid A. |
| Pathways
|
- KDO(2)-lipid A biosynthesis
- Lipopolysaccharide biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| lipopolysaccharide biosynthetic process |
| Kdo2-lipid A biosynthetic process |
| Cellular Component |
| integral to plasma membrane |
| Gram-negative-bacterium-type cell wall |
| Molecular Function |
| myristoyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 314 |
| Molecular Weight
| 36583.455 |
| Theoretical pI
| 9.564 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O06659 |
| UniProtKB/Swiss-Prot Entry Name
| LPXM2_SHIFL |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Buchrieser C, Glaser P, Rusniok C, Nedjari H, D'Hauteville H, Kunst F, Sansonetti P, Parsot C: The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri. Mol Microbiol. 2000 Nov;38(4):760-71. doi: 10.1046/j.1365-2958.2000.02179.x. [PubMed:11115111 ]
- Venkatesan MM, Goldberg MB, Rose DJ, Grotbeck EJ, Burland V, Blattner FR: Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri. Infect Immun. 2001 May;69(5):3271-85. doi: 10.1128/IAI.69.5.3271-3285.2001. [PubMed:11292750 ]
- Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. doi: 10.1093/nar/gkf566. [PubMed:12384590 ]
- D'Hauteville H, Khan S, Maskell DJ, Kussak A, Weintraub A, Mathison J, Ulevitch RJ, Wuscher N, Parsot C, Sansonetti PJ: Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium. J Immunol. 2002 May 15;168(10):5240-51. doi: 10.4049/jimmunol.168.10.5240. [PubMed:11994481 ]
- Goldman SR, Tu Y, Goldberg MB: Differential regulation by magnesium of the two MsbB paralogs of Shigella flexneri. J Bacteriol. 2008 May;190(10):3526-37. doi: 10.1128/JB.00151-08. Epub 2008 Mar 21. [PubMed:18359815 ]
|
