| Identification |
|---|
| HMDB Protein ID
| HMDBP13805 |
| Secondary Accession Numbers
| None |
| Name
| C-X-C chemokine receptor type 4 |
| Synonyms
|
- CXC-R4
- CXCR-4
- Fusin
- Stromal cell-derived factor 1 receptor
- SDF-1 receptor
|
| Gene Name
| CXCR4 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| chemotaxis |
| cellular response to cytokine stimulus |
| CXCL12-activated CXCR4 signaling pathway |
| Cellular Component |
| integral to membrane |
| plasma membrane |
| lysosome |
| cell junction |
| late endosome |
| early endosome |
| Molecular Function |
| cytokine binding |
| C-X-C motif chemokine 12 receptor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 39751.035 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 39-63;78-99;111-130;155-174;196-216;242-261;283-302;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P56491 |
| UniProtKB/Swiss-Prot Entry Name
| CXCR4_PAPAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Benton PA, Lee DR, Kennedy RC: Sequence comparisons of non-human primate HIV-1 coreceptor homologues. Mol Immunol. 1998 Feb;35(2):95-101. doi: 10.1016/s0161-5890(98)00016-9. [PubMed:9683255 ]
|
