Hmdb loader
Identification
HMDB Protein ID HMDBP13791
Secondary Accession Numbers None
Name C-X-C chemokine receptor type 4
Synonyms
  1. CXC-R4
  2. CXCR-4
  3. Fusin
  4. Leukocyte-derived seven transmembrane domain receptor
  5. Pre-B-cell-derived chemokine receptor
  6. Stromal cell-derived factor 1 receptor
  7. LESTR
  8. PB-CKR
  9. SDF-1 receptor
Gene Name CXCR4
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:8962122, PubMed:9295051, PubMed:9103415). Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation (PubMed:9634237, PubMed:9634238, PubMed:9689100). Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells (PubMed:9634237). Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (PubMed:9634238, PubMed:9689100).
Pathways
  • Axon guidance
  • Calcium signaling pathway
  • Chemokine signaling pathway
  • Cytokine-cytokine receptor interaction
  • Endocytosis
  • Human cytomegalovirus infection
  • Human immunodeficiency virus 1 infection
  • Intestinal immune network for IgA production
  • Leukocyte transendothelial migration
  • Regulation of actin cytoskeleton
  • Viral protein interaction with cytokine and cytokine receptor
Reactions Not Available
GO Classification
Biological Process
regulation of chemotaxis
ameboidal-type cell migration
positive regulation of macrophage migration inhibitory factor signaling pathway
CXCL12-activated CXCR4 signaling pathway
positive regulation of dendrite extension
neural precursor cell proliferation
ventricular septum development
aorta development
positive regulation of calcium ion import
branching involved in blood vessel morphogenesis
cell chemotaxis
positive regulation of chemotaxis
T cell proliferation
calcium-mediated signaling
germ cell development
cardiac muscle contraction
germ cell migration
regulation of cell adhesion
detection of mechanical stimulus involved in sensory perception of pain
detection of temperature stimulus involved in sensory perception of pain
endothelial cell differentiation
endothelial tube morphogenesis
generation of neurons
hematopoietic stem cell migration
motor neuron axon guidance
myelin maintenance
positive regulation of cold-induced thermogenesis
positive regulation of mesenchymal stem cell migration
positive regulation of vascular wound healing
regulation of calcium ion transport
regulation of programmed cell death
regulation of viral process
telencephalon cell migration
brain development
nervous system development
epithelial cell development
immune response
neuron migration
kidney development
organ morphogenesis
elevation of cytosolic calcium ion concentration
positive regulation of oligodendrocyte differentiation
positive regulation of ERK1 and ERK2 cascade
neurogenesis
regulation of cell migration
positive regulation of neurogenesis
positive regulation of cell migration
G-protein coupled receptor signaling pathway
positive regulation of protein phosphorylation
cell migration
cellular response to cytokine stimulus
Cellular Component
cell surface
cytoplasm
lysosome
nucleus
external side of plasma membrane
endosome
growth cone
plasma membrane
late endosome
cell leading edge
early endosome
cytoplasmic vesicle
protein-containing complex
integral to membrane
cell-cell junction
Molecular Function
myosin light chain binding
actin binding
C-X-C motif chemokine 12 receptor activity
C-C chemokine receptor activity
C-C chemokine binding
ubiquitin protein ligase binding
identical protein binding
ubiquitin binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 359
Molecular Weight 40425.81
Theoretical pI 8.206
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 41-65;80-101;113-132;157-176;203-223;249-268;290-309;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P70658
UniProtKB/Swiss-Prot Entry Name CXCR4_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Frodl R, Gierschik P, Moepps B: Genomic organization and expression of the CXCR4 gene in mouse and man: absence of a splice variant corresponding to mouse CXCR4-B in human tissues. J Recept Signal Transduct Res. 1998 Jul-Nov;18(4-6):321-44. [PubMed:9879064 ]
  3. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  4. Heesen M, Berman MA, Benson JD, Gerard C, Dorf ME: Cloning of the mouse fusin gene, homologue to a human HIV-1 co-factor. J Immunol. 1996 Dec 15;157(12):5455-60. [PubMed:8955194 ]
  5. Nagasawa T, Nakajima T, Tachibana K, Iizasa H, Bleul CC, Yoshie O, Matsushima K, Yoshida N, Springer TA, Kishimoto T: Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14726-9. doi: 10.1073/pnas.93.25.14726. [PubMed:8962122 ]
  6. Moepps B, Frodl R, Rodewald HR, Baggiolini M, Gierschik P: Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell-derived factor 1alpha activation of Gi2 are differentially expressed in vivo. Eur J Immunol. 1997 Aug;27(8):2102-12. doi: 10.1002/eji.1830270839. [PubMed:9295051 ]
  7. Tachibana K, Hirota S, Iizasa H, Yoshida H, Kawabata K, Kataoka Y, Kitamura Y, Matsushima K, Yoshida N, Nishikawa S, Kishimoto T, Nagasawa T: The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature. 1998 Jun 11;393(6685):591-4. doi: 10.1038/31261. [PubMed:9634237 ]
  8. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR: Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature. 1998 Jun 11;393(6685):595-9. doi: 10.1038/31269. [PubMed:9634238 ]
  9. Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9448-53. doi: 10.1073/pnas.95.16.9448. [PubMed:9689100 ]
  10. McGrath KE, Koniski AD, Maltby KM, McGann JK, Palis J: Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. Dev Biol. 1999 Sep 15;213(2):442-56. doi: 10.1006/dbio.1999.9405. [PubMed:10479460 ]
  11. Bae GU, Gaio U, Yang YJ, Lee HJ, Kang JS, Krauss RS: Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164. J Biol Chem. 2008 Mar 28;283(13):8301-9. doi: 10.1074/jbc.M706730200. Epub 2008 Jan 27. [PubMed:18227060 ]