| Identification |
|---|
| HMDB Protein ID
| HMDBP13774 |
| Secondary Accession Numbers
| None |
| Name
| C-X-C chemokine receptor type 4 |
| Synonyms
|
- CXC-R4
- CXCR-4
- Fusin
- Leukocyte-derived seven transmembrane domain receptor
- Stromal cell-derived factor 1 receptor
- LESTR
- SDF-1 receptor
|
| Gene Name
| CXCR4 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). |
| Pathways
|
- Axon guidance
- Calcium signaling pathway
- Chemokine signaling pathway
- Cytokine-cytokine receptor interaction
- Endocytosis
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Intestinal immune network for IgA production
- Leukocyte transendothelial migration
- Regulation of actin cytoskeleton
- Viral protein interaction with cytokine and cytokine receptor
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| elevation of cytosolic calcium ion concentration |
| CXCL12-activated CXCR4 signaling pathway |
| cell chemotaxis |
| calcium-mediated signaling |
| cellular response to cytokine stimulus |
| neurogenesis |
| immune response |
| brain development |
| viral reproduction |
| Cellular Component |
| late endosome |
| external side of plasma membrane |
| integral to membrane |
| early endosome |
| cell junction |
| lysosome |
| plasma membrane |
| Molecular Function |
| C-C chemokine binding |
| C-C chemokine receptor activity |
| C-X-C motif chemokine 12 receptor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 353 |
| Molecular Weight
| 39935.27 |
| Theoretical pI
| 8.579 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 40-64;79-100;112-131;156-175;197-217;243-262;284-303;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P56498 |
| UniProtKB/Swiss-Prot Entry Name
| CXCR4_FELCA |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Willett BJ, Picard L, Hosie MJ, Turner JD, Adema K, Clapham PR: Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses. J Virol. 1997 Sep;71(9):6407-15. doi: 10.1128/JVI.71.9.6407-6415.1997. [PubMed:9261358 ]
- Kovacs EM, Baxter GD, Robinson WF: Feline peripheral blood mononuclear cells express message for both CXC and CC type chemokine receptors. Arch Virol. 1999;144(2):273-85. doi: 10.1007/s007050050503. [PubMed:10470253 ]
|
