Hmdb loader
Identification
HMDB Protein ID HMDBP13770
Secondary Accession Numbers None
Name BRISC complex subunit Abraxas 2
Synonyms
  1. Abraxas brother protein 1
  2. Protein FAM175B
Gene Name ABRAXAS2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (PubMed:21195082). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
negative regulation of apoptotic process
cell division
chromosome segregation
response to ischemia
attachment of spindle microtubules to kinetochore
cellular response to freezing
mitotic cell cycle
mitotic spindle assembly
protein K63-linked deubiquitination
Cellular Component
cytoplasm
nucleus
microtubule
spindle pole
BRISC complex
Molecular Function
microtubule binding
polyubiquitin binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 424
Molecular Weight 46942.4
Theoretical pI 5.935
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q3TCJ1
UniProtKB/Swiss-Prot Entry Name ABRX2_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  4. Cilenti L, Balakrishnan MP, Wang XL, Ambivero C, Sterlicchi M, del Monte F, Ma XL, Zervos AS: Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination. J Mol Cell Cardiol. 2011 Apr;50(4):652-61. doi: 10.1016/j.yjmcc.2010.12.015. Epub 2010 Dec 30. [PubMed:21195082 ]
  5. Ambivero CT, Cilenti L, Zervos AS: ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway. Biochim Biophys Acta. 2012 Dec;1823(12):2149-56. doi: 10.1016/j.bbamcr.2012.08.020. Epub 2012 Sep 6. [PubMed:22974638 ]
  6. Zheng H, Gupta V, Patterson-Fortin J, Bhattacharya S, Katlinski K, Wu J, Varghese B, Carbone CJ, Aressy B, Fuchs SY, Greenberg RA: A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses. Cell Rep. 2013 Oct 17;5(1):180-93. doi: 10.1016/j.celrep.2013.08.025. Epub 2013 Sep 26. [PubMed:24075985 ]
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