| Identification |
|---|
| HMDB Protein ID
| HMDBP13769 |
| Secondary Accession Numbers
| None |
| Name
| Bifunctional polymyxin resistance protein ArnA |
| Synonyms
|
Not Available
|
| Gene Name
| ARNA |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. |
| Pathways
|
- Amino sugar and nucleotide sugar metabolism
- Cationic antimicrobial peptide (CAMP) resistance
- lipopolysaccharide biosynthesis
- UDP-4-deoxy-4-formamido-beta-L-arabinose biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| response to antibiotic |
| lipopolysaccharide biosynthetic process |
| lipid A biosynthetic process |
| Molecular Function |
| UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity |
| UDP-glucuronic acid dehydrogenase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 660 |
| Molecular Weight
| 74317.275 |
| Theoretical pI
| 7.059 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A1ADA7 |
| UniProtKB/Swiss-Prot Entry Name
| ARNA_ECOK1 |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Johnson TJ, Kariyawasam S, Wannemuehler Y, Mangiamele P, Johnson SJ, Doetkott C, Skyberg JA, Lynne AM, Johnson JR, Nolan LK: The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes. J Bacteriol. 2007 Apr;189(8):3228-36. doi: 10.1128/JB.01726-06. Epub 2007 Feb 9. [PubMed:17293413 ]
|
