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Showing Protein Inactive caspase-12 (HMDBP13756)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13756
Secondary Accession Numbers None
Name Inactive caspase-12
Synonyms
  1. CASP-12
Gene Name CASP12
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
Pathways
  • Alzheimer disease
  • Amyotrophic lateral sclerosis
  • Apoptosis
  • Hepatitis B
  • NOD-like receptor signaling pathway
  • Pathways of neurodegeneration - multiple diseases
  • Prion disease
  • Protein processing in endoplasmic reticulum
Reactions Not Available
GO Classification
Biological Process
regulation of inflammatory response
regulation of apoptotic process
execution phase of apoptosis
Cellular Component
cytoplasm
endoplasmic reticulum
AIM2 inflammasome complex
IPAF inflammasome complex
NLRP3 inflammasome complex
Molecular Function
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 341
Molecular Weight 38906.64
Theoretical pI 6.025
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q6UXS9
UniProtKB/Swiss-Prot Entry Name CASPC_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [PubMed:16554811 ]
  2. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309 ]
  3. Fischer H, Koenig U, Eckhart L, Tschachler E: Human caspase 12 has acquired deleterious mutations. Biochem Biophys Res Commun. 2002 May 3;293(2):722-6. doi: 10.1016/S0006-291X(02)00289-9. [PubMed:12054529 ]
  4. Saleh M, Vaillancourt JP, Graham RK, Huyck M, Srinivasula SM, Alnemri ES, Steinberg MH, Nolan V, Baldwin CT, Hotchkiss RS, Buchman TG, Zehnbauer BA, Hayden MR, Farrer LA, Roy S, Nicholson DW: Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature. 2004 May 6;429(6987):75-9. doi: 10.1038/nature02451. [PubMed:15129283 ]
  5. Kachapati K, O'Brien TR, Bergeron J, Zhang M, Dean M: Population distribution of the functional caspase-12 allele. Hum Mutat. 2006 Sep;27(9):975. doi: 10.1002/humu.9448. [PubMed:16917906 ]