| Identification |
|---|
| HMDB Protein ID
| HMDBP13743 |
| Secondary Accession Numbers
| None |
| Name
| UDP-2,3-diacylglucosamine hydrolase |
| Synonyms
|
- UDP-2,3-diacylglucosamine diphosphatase
|
| Gene Name
| LPXH |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. |
| Pathways
|
- lipid IV(A) biosynthesis
- Lipopolysaccharide biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| lipid A biosynthetic process |
| Cellular Component |
| cytoplasm |
| extrinsic component of plasma membrane |
| Molecular Function |
| manganese ion binding |
| UDP-2,3-diacylglucosamine hydrolase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 240 |
| Molecular Weight
| 26874.845 |
| Theoretical pI
| 7.18 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A1A8J0 |
| UniProtKB/Swiss-Prot Entry Name
| LPXH_ECOK1 |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Johnson TJ, Kariyawasam S, Wannemuehler Y, Mangiamele P, Johnson SJ, Doetkott C, Skyberg JA, Lynne AM, Johnson JR, Nolan LK: The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes. J Bacteriol. 2007 Apr;189(8):3228-36. doi: 10.1128/JB.01726-06. Epub 2007 Feb 9. [PubMed:17293413 ]
|
