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Showing Protein Ninjurin-1 (HMDBP13736)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13736
Secondary Accession Numbers None
Name Ninjurin-1
Synonyms
  1. Nerve injury-induced protein 1
Gene Name NINJ1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Homophilic transmembrane adhesion molecule involved in various processes such as inflammation, cell death, axonal growth, cell chemotaxis and angiogenesis (PubMed:19557008, PubMed:24347169, PubMed:24917672, PubMed:31526566, PubMed:33472215). Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM) (PubMed:24917672, PubMed:30510259). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells (PubMed:24917672, PubMed:30510259). Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding (PubMed:24917672). Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions (By similarity). Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS (PubMed:25860173). Acts as a mediator of both programmed and necrotic cell death (PubMed:19557008, PubMed:33472215). Plays a key role in the induction of plasma membrane rupture during programmed and necrotic cell death: oligomerizes in response to death stimuli to mediate plasma membrane rupture (cytolysis), leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (PubMed:33472215). Plays a role in nerve regeneration by promoting maturation of Schwann cells (PubMed:31526566). Acts as a regulator of angiogenesis (PubMed:25766274, PubMed:30354207). Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells (PubMed:25766274, PubMed:30354207). Also mediates vascular functions in penile tissue as well as vascular formation (PubMed:24979788). Promotes osteoclasts development by enhancing the survival of prefusion osteoclasts (PubMed:30700695). Also involved in striated muscle growth and differentiation (PubMed:31091274). Also involved in cell senescence in a p53/TP53 manner, possibly by acting as an indirect regulator of p53/TP53 mRNA translation (PubMed:23690620, PubMed:29073078).Secreted form generated by cleavage, which has chemotactic activity (PubMed:23142597). Acts as an anti-inflammatory mediator by promoting monocyte recruitment, thereby ameliorating atherosclerosis (PubMed:32883094).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
cell adhesion
tissue regeneration
positive regulation of cell-matrix adhesion
hyaloid vascular plexus regression
Cellular Component
integral to membrane
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 152
Molecular Weight 16555.205
Theoretical pI 6.548
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 80-100;121-141;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O70131
UniProtKB/Swiss-Prot Entry Name NINJ1_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  2. Chadwick BP, Heath SK, Williamson J, Obermayr F, Patel L, Sheer D, Frischauf AM: The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI). Genomics. 1998 Jan 1;47(1):58-63. doi: 10.1006/geno.1997.5084. [PubMed:9465296 ]
  3. Lee HJ, Ahn BJ, Shin MW, Jeong JW, Kim JH, Kim KW: Ninjurin1 mediates macrophage-induced programmed cell death during early ocular development. Cell Death Differ. 2009 Oct;16(10):1395-407. doi: 10.1038/cdd.2009.78. Epub 2009 Jun 26. [PubMed:19557008 ]
  4. Ahn BJ, Le H, Shin MW, Bae SJ, Lee EJ, Wee HJ, Cha JH, Park JH, Lee HS, Lee HJ, Jung H, Park ZY, Park SH, Han BW, Seo JH, Lo EH, Kim KW: The N-terminal ectodomain of Ninjurin1 liberated by MMP9 has chemotactic activity. Biochem Biophys Res Commun. 2012 Nov 30;428(4):438-44. doi: 10.1016/j.bbrc.2012.10.099. Epub 2012 Nov 7. [PubMed:23142597 ]
  5. Cho SJ, Rossi A, Jung YS, Yan W, Liu G, Zhang J, Zhang M, Chen X: Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9362-7. doi: 10.1073/pnas.1221242110. Epub 2013 May 20. [PubMed:23690620 ]
  6. Ahn BJ, Le H, Shin MW, Bae SJ, Lee EJ, Wee HJ, Cha JH, Lee HJ, Lee HS, Kim JH, Kim CY, Seo JH, Lo EH, Jeon S, Lee MN, Oh GT, Yin GN, Ryu JK, Suh JK, Kim KW: Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice. J Biol Chem. 2014 Feb 7;289(6):3328-38. doi: 10.1074/jbc.M113.498212. Epub 2013 Dec 17. [PubMed:24347169 ]
  7. Ahn BJ, Le H, Shin MW, Bae SJ, Lee EJ, Lee SY, Yang JH, Wee HJ, Cha JH, Seo JH, Lee HS, Lee HJ, Arai K, Lo EH, Jeon S, Oh GT, Kim WJ, Ryu JK, Suh JK, Kim KW: Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics. J Biol Chem. 2014 Aug 8;289(32):21926-36. doi: 10.1074/jbc.M113.532358. Epub 2014 Jun 10. [PubMed:24917672 ]
  8. Yin GN, Choi MJ, Kim WJ, Kwon MH, Song KM, Park JM, Das ND, Kwon KD, Batbold D, Oh GT, Koh GY, Kim KW, Ryu JK, Suh JK: Inhibition of Ninjurin 1 restores erectile function through dual angiogenic and neurotrophic effects in the diabetic mouse. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2731-40. doi: 10.1073/pnas.1403471111. Epub 2014 Jun 16. [PubMed:24979788 ]
  9. Jennewein C, Sowa R, Faber AC, Dildey M, von Knethen A, Meybohm P, Scheller B, Drose S, Zacharowski K: Contribution of Ninjurin1 to Toll-like receptor 4 signaling and systemic inflammation. Am J Respir Cell Mol Biol. 2015 Nov;53(5):656-63. doi: 10.1165/rcmb.2014-0354OC. [PubMed:25860173 ]
  10. Matsuki M, Kabara M, Saito Y, Shimamura K, Minoshima A, Nishimura M, Aonuma T, Takehara N, Hasebe N, Kawabe J: Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes. Circ J. 2015;79(6):1363-71. doi: 10.1253/circj.CJ-14-1376. Epub 2015 Mar 11. [PubMed:25766274 ]
  11. Shin MW, Bae SJ, Wee HJ, Lee HJ, Ahn BJ, Le H, Lee EJ, Kim RH, Lee HS, Seo JH, Park JH, Kim KW: Ninjurin1 regulates lipopolysaccharide-induced inflammation through direct binding. Int J Oncol. 2016 Feb;48(2):821-8. doi: 10.3892/ijo.2015.3296. Epub 2015 Dec 15. [PubMed:26677008 ]
  12. Bae SJ, Shin MW, Kim RH, Shin D, Son T, Wee HJ, Kim KW: Ninjurin1 Assembles Into a Homomeric Protein Complex Maintained by N-linked Glycosylation. J Cell Biochem. 2017 Aug;118(8):2219-2230. doi: 10.1002/jcb.25872. Epub 2017 Apr 18. [PubMed:28067406 ]
  13. Le H, Ahn BJ, Lee HS, Shin A, Chae S, Lee SY, Shin MW, Lee EJ, Cha JH, Son T, Seo JH, Wee HJ, Lee HJ, Jang Y, Lo EH, Jeon S, Oh GT, Kim D, Kim KW: Disruption of Ninjurin1 Leads to Repetitive and Anxiety-Like Behaviors in Mice. Mol Neurobiol. 2017 Nov;54(9):7353-7368. doi: 10.1007/s12035-016-0207-6. Epub 2016 Nov 5. [PubMed:27815839 ]
  14. Yang HJ, Zhang J, Yan W, Cho SJ, Lucchesi C, Chen M, Huang EC, Scoumanne A, Zhang W, Chen X: Ninjurin 1 has two opposing functions in tumorigenesis in a p53-dependent manner. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11500-11505. doi: 10.1073/pnas.1711814114. Epub 2017 Oct 9. [PubMed:29073078 ]
  15. Minoshima A, Kabara M, Matsuki M, Yoshida Y, Kano K, Tomita Y, Hayasaka T, Horiuchi K, Saito Y, Aonuma T, Nishimura M, Maruyama K, Nakagawa N, Sawada J, Takehara N, Hasebe N, Kawabe JI: Pericyte-Specific Ninjurin1 Deletion Attenuates Vessel Maturation and Blood Flow Recovery in Hind Limb Ischemia. Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2358-2370. doi: 10.1161/ATVBAHA.118.311375. [PubMed:30354207 ]
  16. Tomita Y, Horiuchi K, Kano K, Tatsukawa T, Matsuo R, Hayasaka T, Yoshida Y, Kabara M, Yasuda S, Nakajima K, Nakagawa N, Takehara N, Okizaki A, Hasebe N, Kawabe JI: Ninjurin 1 mediates peripheral nerve regeneration through Schwann cell maturation of NG2-positive cells. Biochem Biophys Res Commun. 2019 Nov 12;519(3):462-468. doi: 10.1016/j.bbrc.2019.09.007. Epub 2019 Sep 13. [PubMed:31526566 ]
  17. Bae SJ, Shin MW, Son T, Lee HS, Chae JS, Jeon S, Oh GT, Kim KW: Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts. Exp Mol Med. 2019 Jan 16;51(1):1-16. doi: 10.1038/s12276-018-0201-3. [PubMed:30700695 ]
  18. Kny M, Csalyi KD, Klaeske K, Busch K, Meyer AM, Merks AM, Darm K, Dworatzek E, Fliegner D, Baczko I, Regitz-Zagrosek V, Butter C, Luft FC, Panakova D, Fielitz J: Ninjurin1 regulates striated muscle growth and differentiation. PLoS One. 2019 May 15;14(5):e0216987. doi: 10.1371/journal.pone.0216987. eCollection 2019. [PubMed:31091274 ]
  19. Jeon S, Kim TK, Jeong SJ, Jung IH, Kim N, Lee MN, Sonn SK, Seo S, Jin J, Kweon HY, Kim S, Shim D, Park YM, Lee SH, Kim KW, Cybulsky MI, Shim H, Roh TY, Park WY, Lee HO, Choi JH, Park SH, Oh GT: Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis. Circulation. 2020 Nov 3;142(18):1736-1751. doi: 10.1161/CIRCULATIONAHA.120.046907. Epub 2020 Sep 4. [PubMed:32883094 ]
  20. Kayagaki N, Kornfeld OS, Lee BL, Stowe IB, O'Rourke K, Li Q, Sandoval W, Yan D, Kang J, Xu M, Zhang J, Lee WP, McKenzie BS, Ulas G, Payandeh J, Roose-Girma M, Modrusan Z, Reja R, Sagolla M, Webster JD, Cho V, Andrews TD, Morris LX, Miosge LA, Goodnow CC, Bertram EM, Dixit VM: NINJ1 mediates plasma membrane rupture during lytic cell death. Nature. 2021 Mar;591(7848):131-136. doi: 10.1038/s41586-021-03218-7. Epub 2021 Jan 20. [PubMed:33472215 ]