| Identification |
|---|
| HMDB Protein ID
| HMDBP13731 |
| Secondary Accession Numbers
| None |
| Name
| Antileukoproteinase |
| Synonyms
|
- ALP
- Secretory leukocyte protease inhibitor
|
| Gene Name
| SLPI |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| innate immune response |
| response to lipopolysaccharide |
| immune response |
| antibacterial humoral response |
| Cellular Component |
| extracellular space |
| Molecular Function |
| endopeptidase inhibitor activity |
| serine-type endopeptidase inhibitor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 129 |
| Molecular Weight
| Not Available |
| Theoretical pI
| 8.746 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P22298 |
| UniProtKB/Swiss-Prot Entry Name
| SLPI_PIG |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Farmer SJ, Fliss AE, Simmen RC: Complementary DNA cloning and regulation of expression of the messenger RNA encoding a pregnancy-associated porcine uterine protein related to human antileukoproteinase. Mol Endocrinol. 1990 Aug;4(8):1095-104. doi: 10.1210/mend-4-8-1095. [PubMed:2293019 ]
- Simmen RC, Michel FJ, Fliss AE, Smith LC, Fliss MF: Ontogeny, immunocytochemical localization, and biochemical properties of the pregnancy-associated uterine elastase/cathepsin-G protease inhibitor, antileukoproteinase (ALP): monospecific antibodies to a synthetic peptide recognize native ALP. Endocrinology. 1992 Apr;130(4):1957-65. doi: 10.1210/endo.130.4.1547723. [PubMed:1547723 ]
|
