| Identification |
|---|
| HMDB Protein ID
| HMDBP13709 |
| Secondary Accession Numbers
| None |
| Name
| Secoisolariciresinol dehydrogenase |
| Synonyms
|
Not Available
|
| Gene Name
| (KEGG) SECOISOLARICIRESINOL DEHYDROGENASE (EC:1.1.1.331) |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Oxidoreductase involved in lignan biosynthesis. Catalyzes the stereospecific conversion of (-)-secoisolariciresinol to (-)-matairesinol via a lactol intermediate. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| protein homotetramerization |
| lignan biosynthetic process |
| Molecular Function |
| nucleotide binding |
| (-)-secoisolariciresinol dehydrogenase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 278 |
| Molecular Weight
| 29252.965 |
| Theoretical pI
| 6.154 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q94KL8 |
| UniProtKB/Swiss-Prot Entry Name
| SILD_PODPE |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Xia ZQ, Costa MA, Pelissier HC, Davin LB, Lewis NG: Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection. J Biol Chem. 2001 Apr 20;276(16):12614-23. doi: 10.1074/jbc.M008622200. Epub 2001 Jan 18. [PubMed:11278426 ]
- Moinuddin SG, Youn B, Bedgar DL, Costa MA, Helms GL, Kang C, Davin LB, Lewis NG: Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum. Org Biomol Chem. 2006 Mar 7;4(5):808-16. doi: 10.1039/b516563f. Epub 2006 Jan 30. [PubMed:16493463 ]
- Youn B, Moinuddin SG, Davin LB, Lewis NG, Kang C: Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans. J Biol Chem. 2005 Apr 1;280(13):12917-26. doi: 10.1074/jbc.M413266200. Epub 2005 Jan 13. [PubMed:15653677 ]
|
