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Showing Protein Transcriptional coregulator SSA1 (HMDBP13698)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13698
Secondary Accession Numbers None
Name Transcriptional coregulator SSA1
Synonyms Not Available
Gene Name SSA1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transcriptional coregulator that functions together with transcription factor HSF1 (PubMed:17040492). Positively regulates the expression of laccase LAC1 during glucose starvation (PubMed:17040492).
Pathways
  • Endocytosis
  • Protein processing in endoplasmic reticulum
  • Spliceosome
Reactions Not Available
GO Classification
Biological Process
vesicle-mediated transport
cellular response to unfolded protein
chaperone cofactor-dependent protein refolding
protein refolding
Cellular Component
cytosol
cytoplasm
plasma membrane
nucleus
Molecular Function
ATP binding
transcription cofactor activity
ATPase activity
heat shock protein binding
unfolded protein binding
misfolded protein binding
protein folding chaperone
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 640
Molecular Weight 69352.365
Theoretical pI 5.044
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q5KKP4
UniProtKB/Swiss-Prot Entry Name HSP71_CRYNJ
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Loftus BJ, Fung E, Roncaglia P, Rowley D, Amedeo P, Bruno D, Vamathevan J, Miranda M, Anderson IJ, Fraser JA, Allen JE, Bosdet IE, Brent MR, Chiu R, Doering TL, Donlin MJ, D'Souza CA, Fox DS, Grinberg V, Fu J, Fukushima M, Haas BJ, Huang JC, Janbon G, Jones SJ, Koo HL, Krzywinski MI, Kwon-Chung JK, Lengeler KB, Maiti R, Marra MA, Marra RE, Mathewson CA, Mitchell TG, Pertea M, Riggs FR, Salzberg SL, Schein JE, Shvartsbeyn A, Shin H, Shumway M, Specht CA, Suh BB, Tenney A, Utterback TR, Wickes BL, Wortman JR, Wye NH, Kronstad JW, Lodge JK, Heitman J, Davis RW, Fraser CM, Hyman RW: The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science. 2005 Feb 25;307(5713):1321-4. doi: 10.1126/science.1103773. Epub 2005 Jan 13. [PubMed:15653466 ]
  2. Zhang S, Hacham M, Panepinto J, Hu G, Shin S, Zhu X, Williamson PR: The Hsp70 member, Ssa1, acts as a DNA-binding transcriptional co-activator of laccase in Cryptococcus neoformans. Mol Microbiol. 2006 Nov;62(4):1090-101. doi: 10.1111/j.1365-2958.2006.05422.x. Epub 2006 Oct 16. [PubMed:17040492 ]
  3. Eastman AJ, He X, Qiu Y, Davis MJ, Vedula P, Lyons DM, Park YD, Hardison SE, Malachowski AN, Osterholzer JJ, Wormley FL Jr, Williamson PR, Olszewski MA: Cryptococcal heat shock protein 70 homolog Ssa1 contributes to pulmonary expansion of Cryptococcus neoformans during the afferent phase of the immune response by promoting macrophage M2 polarization. J Immunol. 2015 Jun 15;194(12):5999-6010. doi: 10.4049/jimmunol.1402719. Epub 2015 May 13. [PubMed:25972480 ]