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Showing Protein Conidial pigment polyketide synthase alb1 (HMDBP13697)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13697
Secondary Accession Numbers None
Name Conidial pigment polyketide synthase alb1
Synonyms
  1. Conidial pigment biosynthesis protein alb1
  2. Naphthopyrone synthase
Gene Name ALB1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall (PubMed:9620950, PubMed:10515939, PubMed:18539819, PubMed:19156203). The first step of the pathway is the production of the heptaketide naphtopyrone YWA1 by the polyketide synthase alb1 though condensation of acetyl-CoA with malonyl-CoA (PubMed:9620950, PubMed:11040426). The naphtopyrone YWA1 is then converted to the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN) by the heptaketide hydrolyase ayg1 though chain-length shortening (PubMed:10515939, PubMed:11350964). 1,3,6,8-THN is substrate of the hydroxynaphthalene reductase arp2 to yield scytalone (PubMed:10515939). The scytalone dehydratase arp1 then reduces scytalone to 1,3,8-THN (PubMed:10515939). 1,3,8-THN is also substrate of the hydroxynaphthalene reductase arp2 to yield vermelone (PubMed:10515939). Vermelone is further converted by the multicopper oxidase abr1 to 1,8-DHN (PubMed:10515939). Finally the laccase abr2 transforms 1,8-DHN to DHN-melanin (PubMed:10515939). DHN-melanin biosynthesis appears to be initiated in endosomes where early enzymes (abl1, ayg1, arp1 and arp2) localize, with exocytosis leading to melanin deposition on the cell surface where late enzymes (abr1 and abr2) localize (PubMed:26972005). DHN-melanin is an important structural component of the outer cell wall and is required for the presence of conidial surface hydrophobins (PubMed:19703288). DHN-melanin plays also a crucial role in fungal virulence, including a protective role against the host's immune defenses (PubMed:9620950, PubMed:9832321, PubMed:12464010,PubMed:16110796, PubMed:20145078, PubMed:21501368, PubMed:21747802, PubMed:21573171, PubMed:24818666, PubMed:24836942, PubMed:25810442, PubMed:26972005). DHN-melanin protects also conidia against amoeba predation (PubMed:25684622).
Pathways
  • melanin biosynthesis
Reactions Not Available
GO Classification
Biological Process
fatty acid biosynthetic process
pathogenesis
spermidine biosynthetic process
melanin biosynthetic process
secondary metabolic process
pigment biosynthetic process
asexual spore wall assembly
response to host
suppression by symbiont of microbe-associated molecular pattern-induced host innate immune response
Cellular Component
endosome
Molecular Function
adenosylmethionine decarboxylase activity
3-oxoacyl-[acyl-carrier-protein] synthase activity
phosphopantetheine binding
complement binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 2146
Molecular Weight 234491.355
Theoretical pI 6.326
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q4WZA8
UniProtKB/Swiss-Prot Entry Name ALB1_ASPFU
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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