Hmdb loader

Showing Protein Copper-dependent transcription factor 1 (HMDBP13696)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13696
Secondary Accession Numbers None
Name Copper-dependent transcription factor 1
Synonyms Not Available
Gene Name CUF1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transcription factor that regulates copper acquisition and homeostasis, and which plays a central role in fungal pathogenesis during neurologic infection (PubMed:21489137, PubMed:23511945, PubMed:29608794). The transcriptional regulation exerted by CUF1 is intrinsically complex since it acts as a dual sensor of copper levels, responsible for expression of a set of copper-specific copper transporters, CTR1 and CTR4, at low copper concentrations, and 2 metallothioneins, CMT1 and CMT2, at high copper concentrations (PubMed:17290306, PubMed:21489137, PubMed:21819456, PubMed:29608794). Positively regulates the expression of the copper acquisition factor BIM1 under copper-limiting conditions (PubMed:31932719). Regulates also ATM1, an ABC transporter with functions in the iron-sulfur clusters (ISC) export machinery, during copper stress (PubMed:29089435). Another target of CUF1 is the gene encoding the laccase LAC1 (PubMed:19459959). Binds promoters of target genes at Cu-responsive elements (CuREs) that contain a variable A/T rich 5' region followed by the core consensus sequence 5'-G(G/C)CTC(A/G)-3' (PubMed:29608794, PubMed:31932719). Negatively regulates capsule biosynthesis, probably via modulating iron acquisition through the high-affinity iron uptake pathway (PubMed:20112673).
Pathways Not Available
Reactions Not Available
GO Classification
Cellular Component
nucleus
cell cortex
Molecular Function
copper ion binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 110780.225
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID J9VT33
UniProtKB/Swiss-Prot Entry Name CUF1_CRYNH
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Janbon G, Ormerod KL, Paulet D, Byrnes EJ 3rd, Yadav V, Chatterjee G, Mullapudi N, Hon CC, Billmyre RB, Brunel F, Bahn YS, Chen W, Chen Y, Chow EW, Coppee JY, Floyd-Averette A, Gaillardin C, Gerik KJ, Goldberg J, Gonzalez-Hilarion S, Gujja S, Hamlin JL, Hsueh YP, Ianiri G, Jones S, Kodira CD, Kozubowski L, Lam W, Marra M, Mesner LD, Mieczkowski PA, Moyrand F, Nielsen K, Proux C, Rossignol T, Schein JE, Sun S, Wollschlaeger C, Wood IA, Zeng Q, Neuveglise C, Newlon CS, Perfect JR, Lodge JK, Idnurm A, Stajich JE, Kronstad JW, Sanyal K, Heitman J, Fraser JA, Cuomo CA, Dietrich FS: Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. PLoS Genet. 2014 Apr 17;10(4):e1004261. doi: 10.1371/journal.pgen.1004261. eCollection 2014 Apr. [PubMed:24743168 ]
  2. Waterman SR, Hacham M, Hu G, Zhu X, Park YD, Shin S, Panepinto J, Valyi-Nagy T, Beam C, Husain S, Singh N, Williamson PR: Role of a CUF1/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformans. J Clin Invest. 2007 Mar;117(3):794-802. doi: 10.1172/JCI30006. Epub 2007 Feb 8. [PubMed:17290306 ]
  3. Jiang N, Sun N, Xiao D, Pan J, Wang Y, Zhu X: A copper-responsive factor gene CUF1 is required for copper induction of laccase in Cryptococcus neoformans. FEMS Microbiol Lett. 2009 Jul;296(1):84-90. doi: 10.1111/j.1574-6968.2009.01619.x. Epub 2009 May 11. [PubMed:19459959 ]
  4. Jiang N, Liu X, Pan J, Wang Y, Zhu X: Effect of the copper-responsive factor Cuf1 on the capsule biosynthesis in Cryptococcus neoformans. Wei Sheng Wu Xue Bao. 2009 Nov;49(11):1459-64. [PubMed:20112673 ]
  5. Jiang N, Liu X, Yang J, Li Z, Pan J, Zhu X: Regulation of copper homeostasis by Cuf1 associates with its subcellular localization in the pathogenic yeast Cryptococcus neoformans H99. FEMS Yeast Res. 2011 Aug;11(5):440-8. doi: 10.1111/j.1567-1364.2011.00733.x. Epub 2011 May 18. [PubMed:21489137 ]
  6. Ding C, Yin J, Tovar EM, Fitzpatrick DA, Higgins DG, Thiele DJ: The copper regulon of the human fungal pathogen Cryptococcus neoformans H99. Mol Microbiol. 2011 Sep;81(6):1560-76. doi: 10.1111/j.1365-2958.2011.07794.x. Epub 2011 Aug 23. [PubMed:21819456 ]
  7. Raja MR, Waterman SR, Qiu J, Bleher R, Williamson PR, O'Halloran TV: A copper hyperaccumulation phenotype correlates with pathogenesis in Cryptococcus neoformans. Metallomics. 2013 Apr;5(4):363-71. doi: 10.1039/c3mt20220h. [PubMed:23511945 ]
  8. Garcia-Santamarina S, Uzarska MA, Festa RA, Lill R, Thiele DJ: Cryptococcus neoformans Iron-Sulfur Protein Biogenesis Machinery Is a Novel Layer of Protection against Cu Stress. mBio. 2017 Oct 31;8(5). pii: mBio.01742-17. doi: 10.1128/mBio.01742-17. [PubMed:29089435 ]
  9. Garcia-Santamarina S, Festa RA, Smith AD, Yu CH, Probst C, Ding C, Homer CM, Yin J, Noonan JP, Madhani H, Perfect JR, Thiele DJ: Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans. Mol Microbiol. 2018 Jun;108(5):473-494. doi: 10.1111/mmi.13960. Epub 2018 Apr 24. [PubMed:29608794 ]
  10. Garcia-Santamarina S, Probst C, Festa RA, Ding C, Smith AD, Conklin SE, Brander S, Kinch LN, Grishin NV, Franz KJ, Riggs-Gelasco P, Lo Leggio L, Johansen KS, Thiele DJ: A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis. Nat Chem Biol. 2020 Mar;16(3):337-344. doi: 10.1038/s41589-019-0437-9. Epub 2020 Jan 13. [PubMed:31932719 ]