| Identification |
|---|
| HMDB Protein ID
| HMDBP13676 |
| Secondary Accession Numbers
| None |
| Name
| Kallikrein-1E2 |
| Synonyms
|
- Glandular kallikrein
- HPK
|
| Gene Name
| KLK1E2 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. |
| Pathways
|
- Endocrine and other factor-regulated calcium reabsorption
- Renin-angiotensin system
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| regulation of systemic arterial blood pressure |
| zymogen activation |
| Cellular Component |
| extracellular region |
| secretory granule |
| Molecular Function |
| serine-type endopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 261 |
| Molecular Weight
| 29392.2 |
| Theoretical pI
| 5.723 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q6H321 |
| UniProtKB/Swiss-Prot Entry Name
| KLK2_HORSE |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Olsson AY, Lilja H, Lundwall A: Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen. Genomics. 2004 Jul;84(1):147-56. doi: 10.1016/j.ygeno.2004.01.009. [PubMed:15203212 ]
- Carvalho AL, Sanz L, Barettino D, Romero A, Calvete JJ, Romao MJ: Crystal structure of a prostate kallikrein isolated from stallion seminal plasma: a homologue of human PSA. J Mol Biol. 2002 Sep 13;322(2):325-37. doi: 10.1016/s0022-2836(02)00705-2. [PubMed:12217694 ]
|
