| Identification |
|---|
| HMDB Protein ID
| HMDBP13672 |
| Secondary Accession Numbers
| None |
| Name
| Relaxin-3 receptor 2 |
| Synonyms
|
- RLN3 receptor 2
- G-protein coupled receptor 100
- Insulin-like peptide INSL5 receptor
- Relaxin family peptide receptor 4
|
| Gene Name
| RXFP4 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation (By similarity). |
| Pathways
|
- Neuroactive ligand-receptor interaction
- Relaxin signaling pathway
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| neuropeptide signaling pathway |
| positive regulation of feeding behavior |
| Cellular Component |
| integral to plasma membrane |
| Molecular Function |
| G-protein coupled peptide receptor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 414 |
| Molecular Weight
| 45459.635 |
| Theoretical pI
| 8.105 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 44-64;78-98;117-137;156-176;210-230;256-276;294-316;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q7TQP4 |
| UniProtKB/Swiss-Prot Entry Name
| RL3R2_MOUSE |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB: Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 2003 Nov 20;554(3):381-8. [PubMed:14623098 ]
- Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA: The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8. doi: 10.1073/pnas.0230374100. Epub 2003 Apr 4. [PubMed:12679517 ]
|
