| Identification |
|---|
| HMDB Protein ID
| HMDBP13670 |
| Secondary Accession Numbers
| None |
| Name
| Scavenger receptor cysteine-rich type 1 protein M130 |
| Synonyms
|
Not Available
|
| Gene Name
| CD163 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV). In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry.After shedding, the soluble form (sCD163) may play an anti-inflammatory role. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| acute-phase response |
| Cellular Component |
| integral to membrane |
| extracellular region |
| external side of plasma membrane |
| Molecular Function |
| viral receptor activity |
| scavenger receptor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 1115 |
| Molecular Weight
| 120455.7 |
| Theoretical pI
| 5.979 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q2VL90 |
| UniProtKB/Swiss-Prot Entry Name
| C163A_PIG |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Sanchez-Torres C, Gomez-Puertas P, Gomez-del-Moral M, Alonso F, Escribano JM, Ezquerra A, Dominguez J: Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection. Arch Virol. 2003 Dec;148(12):2307-23. doi: 10.1007/s00705-003-0188-4. Epub 2003 Sep 16. [PubMed:14648288 ]
- Chamorro S, Revilla C, Gomez N, Alvarez B, Alonso F, Ezquerra A, Dominguez J: In vitro differentiation of porcine blood CD163- and CD163+ monocytes into functional dendritic cells. Immunobiology. 2004;209(1-2):57-65. doi: 10.1016/j.imbio.2004.02.002. [PubMed:15481141 ]
- Das PB, Dinh PX, Ansari IH, de Lima M, Osorio FA, Pattnaik AK: The minor envelope glycoproteins GP2a and GP4 of porcine reproductive and respiratory syndrome virus interact with the receptor CD163. J Virol. 2010 Feb;84(4):1731-40. doi: 10.1128/JVI.01774-09. Epub 2009 Nov 25. [PubMed:19939927 ]
|
