| Identification |
|---|
| HMDB Protein ID
| HMDBP13664 |
| Secondary Accession Numbers
| None |
| Name
| Phosphatidylinositol-glycan-specific phospholipase D |
| Synonyms
|
- PI-G PLD
- Glycoprotein phospholipase D
- Glycosyl-phosphatidylinositol-specific phospholipase D
- GPI-PLD
- GPI-specific phospholipase D
|
| Gene Name
| GPLD1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. |
| Pathways
|
- Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| negative regulation of triglyceride catabolic process |
| positive regulation of high-density lipoprotein particle clearance |
| positive regulation of endothelial cell migration |
| phosphatidylcholine metabolic process |
| cell migration involved in sprouting angiogenesis |
| cellular response to triglyceride |
| chondrocyte differentiation |
| complement receptor mediated signaling pathway |
| GPI anchor release |
| cellular response to cholesterol |
| positive regulation of alkaline phosphatase activity |
| positive regulation of glucose metabolic process |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| positive regulation of membrane protein ectodomain proteolysis |
| regulation of cellular response to insulin stimulus |
| transepithelial transport |
| cellular response to inorganic substance |
| cellular response to iron(II) ion |
| cellular response to pH |
| cellular response to insulin stimulus |
| insulin receptor signaling pathway |
| cellular response to calcium ion |
| cellular response to drug |
| ossification |
| negative regulation of cell proliferation |
| positive regulation of apoptotic process |
| response to glucose stimulus |
| positive regulation of triglyceride biosynthetic process |
| positive regulation of secretion |
| Cellular Component |
| cytoplasm |
| extracellular space |
| extracellular region |
| intracellular membrane-bounded organelle |
| extracellular matrix |
| high-density lipoprotein particle |
| Molecular Function |
| glycosylphosphatidylinositol phospholipase D activity |
| sodium channel regulator activity |
| phospholipase D activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 843 |
| Molecular Weight
| 93780.95 |
| Theoretical pI
| 6.653 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q8R2H5 |
| UniProtKB/Swiss-Prot Entry Name
| PHLD_RAT |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Schofield JN, Stephens JW, Hurel SJ, Bell KM, deSouza JB, Rademacher TW: Insulin reduces serum glycosylphosphatidylinositol phospholipase D levels in human type I diabetic patients and streptozotocin diabetic rats. Mol Genet Metab. 2002 Feb;75(2):154-61. doi: 10.1006/mgme.2001.3287. [PubMed:11855934 ]
|
