| Identification |
|---|
| HMDB Protein ID
| HMDBP13660 |
| Secondary Accession Numbers
| None |
| Name
| N-acetyllactosaminide alpha-1,3-galactosyltransferase |
| Synonyms
|
- UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase
- Galactosyltransferase
|
| Gene Name
| GGTA1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isoglobotrihexosylceramide or isogloboside 3 (iGb3). |
| Pathways
|
- Glycosphingolipid biosynthesis - lacto and neolacto series
- protein glycosylation
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| carbohydrate metabolic process |
| lipid glycosylation |
| protein galactosylation at cell surface |
| Cellular Component |
| integral to membrane |
| Golgi apparatus |
| Golgi cisterna membrane |
| vesicle |
| Golgi cisterna |
| Molecular Function |
| metal ion binding |
| transferase activity, transferring glycosyl groups |
| N-acetyllactosaminide 3-alpha-galactosyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 368 |
| Molecular Weight
| 43246.325 |
| Theoretical pI
| 6.539 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P14769 |
| UniProtKB/Swiss-Prot Entry Name
| GGTA1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Joziasse DH, Shaper JH, Van den Eijnden DH, Van Tunen AJ, Shaper NL: Bovine alpha 1----3-galactosyltransferase: isolation and characterization of a cDNA clone. Identification of homologous sequences in human genomic DNA. J Biol Chem. 1989 Aug 25;264(24):14290-7. [PubMed:2503516 ]
- Gastinel LN, Bignon C, Misra AK, Hindsgaul O, Shaper JH, Joziasse DH: Bovine alpha1,3-galactosyltransferase catalytic domain structure and its relationship with ABO histo-blood group and glycosphingolipid glycosyltransferases. EMBO J. 2001 Feb 15;20(4):638-49. doi: 10.1093/emboj/20.4.638. [PubMed:11179209 ]
- Boix E, Swaminathan GJ, Zhang Y, Natesh R, Brew K, Acharya KR: Structure of UDP complex of UDP-galactose:beta-galactoside-alpha -1,3-galactosyltransferase at 1.53-A resolution reveals a conformational change in the catalytically important C terminus. J Biol Chem. 2001 Dec 21;276(51):48608-14. doi: 10.1074/jbc.M108828200. Epub 2001 Oct 9. [PubMed:11592969 ]
- Boix E, Zhang Y, Swaminathan GJ, Brew K, Acharya KR: Structural basis of ordered binding of donor and acceptor substrates to the retaining glycosyltransferase, alpha-1,3-galactosyltransferase. J Biol Chem. 2002 Aug 2;277(31):28310-8. doi: 10.1074/jbc.M202631200. Epub 2002 May 14. [PubMed:12011052 ]
|
