| Identification |
|---|
| HMDB Protein ID
| HMDBP13650 |
| Secondary Accession Numbers
| None |
| Name
| Protoheme IX farnesyltransferase |
| Synonyms
|
- Heme B farnesyltransferase
- Heme O synthase
|
| Gene Name
| CYOE |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. |
| Pathways
|
- Biosynthesis of cofactors
- Biosynthesis of secondary metabolites
- heme O biosynthesis
- Oxidative phosphorylation
- Porphyrin and chlorophyll metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| heme O biosynthetic process |
| Cellular Component |
| integral to membrane |
| plasma membrane |
| Molecular Function |
| protoheme IX farnesyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 282 |
| Molecular Weight
| 31542.745 |
| Theoretical pI
| 9.045 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 9-29;39-59;79-99;102-122;139-159;165-185;210-230;231-251;261-281;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A0Q4E4 |
| UniProtKB/Swiss-Prot Entry Name
| CYOE_FRATN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Rohmer L, Fong C, Abmayr S, Wasnick M, Larson Freeman TJ, Radey M, Guina T, Svensson K, Hayden HS, Jacobs M, Gallagher LA, Manoil C, Ernst RK, Drees B, Buckley D, Haugen E, Bovee D, Zhou Y, Chang J, Levy R, Lim R, Gillett W, Guenthener D, Kang A, Shaffer SA, Taylor G, Chen J, Gallis B, D'Argenio DA, Forsman M, Olson MV, Goodlett DR, Kaul R, Miller SI, Brittnacher MJ: Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains. Genome Biol. 2007;8(6):R102. doi: 10.1186/gb-2007-8-6-r102. [PubMed:17550600 ]
|
