| Identification |
|---|
| HMDB Protein ID
| HMDBP13620 |
| Secondary Accession Numbers
| None |
| Name
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 |
| Synonyms
|
- HMG-CoA reductase 1
|
| Gene Name
| HMG1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| One of 2 isozymes that catalyze the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis. |
| Pathways
|
- (R)-mevalonate biosynthesis
- Biosynthesis of secondary metabolites
- Terpenoid backbone biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| coenzyme A metabolic process |
| sterol biosynthetic process |
| isoprenoid biosynthetic process |
| isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| ergosterol biosynthetic process |
| Cellular Component |
| integral to membrane |
| endoplasmic reticulum membrane |
| peroxisomal membrane |
| nuclear envelope |
| nuclear periphery |
| Molecular Function |
| hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| hydroxymethylglutaryl-CoA reductase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 1054 |
| Molecular Weight
| 115624.355 |
| Theoretical pI
| 8.002 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 29-49;188-208;218-238;247-267;310-330;337-357;401-421;499-519;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P12683 |
| UniProtKB/Swiss-Prot Entry Name
| HMDH1_YEAST |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995. [PubMed:24374639 ]
- Li X, Gerber SA, Rudner AD, Beausoleil SA, Haas W, Villen J, Elias JE, Gygi SP: Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae. J Proteome Res. 2007 Mar;6(3):1190-7. doi: 10.1021/pr060559j. [PubMed:17330950 ]
- Holt LJ, Tuch BB, Villen J, Johnson AD, Gygi SP, Morgan DO: Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science. 2009 Sep 25;325(5948):1682-6. doi: 10.1126/science.1172867. [PubMed:19779198 ]
- Basson ME, Thorsness M, Finer-Moore J, Stroud RM, Rine J: Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis. Mol Cell Biol. 1988 Sep;8(9):3797-808. doi: 10.1128/mcb.8.9.3797-3808.1988. [PubMed:3065625 ]
- Basson ME, Thorsness M, Rine J: Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc Natl Acad Sci U S A. 1986 Aug;83(15):5563-7. doi: 10.1073/pnas.83.15.5563. [PubMed:3526336 ]
- Koning AJ, Roberts CJ, Wright RL: Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations. Mol Biol Cell. 1996 May;7(5):769-89. doi: 10.1091/mbc.7.5.769. [PubMed:8744950 ]
- Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O'Shea EK: Global analysis of protein localization in budding yeast. Nature. 2003 Oct 16;425(6959):686-91. doi: 10.1038/nature02026. [PubMed:14562095 ]
- Bowman S, Churcher C, Badcock K, Brown D, Chillingworth T, Connor R, Dedman K, Devlin K, Gentles S, Hamlin N, Hunt S, Jagels K, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Skelton J, Walsh S, Whitehead S, Barrell B: The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII. Nature. 1997 May 29;387(6632 Suppl):90-3. [PubMed:9169872 ]
- Donald KA, Hampton RY, Fritz IB: Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae. Appl Environ Microbiol. 1997 Sep;63(9):3341-4. doi: 10.1128/aem.63.9.3341-3344.1997. [PubMed:9292983 ]
|
