| Identification |
|---|
| HMDB Protein ID
| HMDBP13593 |
| Secondary Accession Numbers
| None |
| Name
| Guanylate cyclase D |
| Synonyms
|
Not Available
|
| Gene Name
| GUCY2D |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Functions as an olfactory receptor activated by urine odorants, uroguanylin and guanylin and as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2) (PubMed:17724338, PubMed:17702944, PubMed:20637621). Has guanylate cyclase activity upon binding of the ligand (By similarity). Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency (PubMed:17724338, PubMed:20637621). Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference (PubMed:20637621). |
| Pathways
|
- Olfactory transduction
- Phototransduction
- Purine metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| positive regulation of cGMP-mediated signaling |
| olfactory learning |
| intracellular signal transduction |
| sensory perception of smell |
| olfactory behavior |
| detection of chemical stimulus involved in sensory perception of smell |
| detection of carbon dioxide |
| receptor guanylyl cyclase signaling pathway |
| signal transduction |
| cGMP biosynthetic process |
| Cellular Component |
| ciliary membrane |
| non-motile cilium |
| integral to membrane |
| plasma membrane |
| Molecular Function |
| odorant binding |
| olfactory receptor activity |
| peptide receptor activity |
| protein kinase activity |
| natriuretic peptide receptor activity |
| guanylate cyclase activity |
| ATP binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 1117 |
| Molecular Weight
| 122527.16 |
| Theoretical pI
| 6.59 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A0A0U1RPR8 |
| UniProtKB/Swiss-Prot Entry Name
| GUC2D_MOUSE |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP: Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009 May 5;7(5):e1000112. doi: 10.1371/journal.pbio.1000112. Epub 2009 May 26. [PubMed:19468303 ]
- Juilfs DM, Fulle HJ, Zhao AZ, Houslay MD, Garbers DL, Beavo JA: A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3388-95. doi: 10.1073/pnas.94.7.3388. [PubMed:9096404 ]
- Leinders-Zufall T, Cockerham RE, Michalakis S, Biel M, Garbers DL, Reed RR, Zufall F, Munger SD: Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14507-12. doi: 10.1073/pnas.0704965104. Epub 2007 Aug 27. [PubMed:17724338 ]
- Hu J, Zhong C, Ding C, Chi Q, Walz A, Mombaerts P, Matsunami H, Luo M: Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse. Science. 2007 Aug 17;317(5840):953-7. doi: 10.1126/science.1144233. [PubMed:17702944 ]
- Munger SD, Leinders-Zufall T, McDougall LM, Cockerham RE, Schmid A, Wandernoth P, Wennemuth G, Biel M, Zufall F, Kelliher KR: An olfactory subsystem that detects carbon disulfide and mediates food-related social learning. Curr Biol. 2010 Aug 24;20(16):1438-44. doi: 10.1016/j.cub.2010.06.021. Epub 2010 Jul 15. [PubMed:20637621 ]
|
