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Showing Protein Synaptotagmin-7 (HMDBP13581)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13581
Secondary Accession Numbers None
Name Synaptotagmin-7
Synonyms
  1. Protein Syt7
  2. Synaptotagmin VII
  3. SytVII
Gene Name SYT7
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (PubMed:11395007, PubMed:10725327, PubMed:11511344). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (PubMed:11395007). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:10725327, PubMed:11511344). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages. Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts. Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes. Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters. Probably mediates synaptic facilitation by directly increasing the probability of release. May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin. Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells. Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (PubMed:15456748).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
regulation of bone remodeling
phagosome-lysosome fusion
regulation of synaptic vesicle endocytosis
regulation of glucagon secretion
phagocytosis
vesicle-mediated transport
calcium ion-dependent exocytosis
calcium ion regulated lysosome exocytosis
calcium ion-regulated exocytosis of neurotransmitter
calcium-dependent activation of synaptic vesicle fusion
regulation of insulin secretion
plasma membrane repair
regulation of calcium ion-dependent exocytosis
regulation of dopamine secretion
regulation of phagocytosis
short-term synaptic potentiation
synaptic vesicle recycling
vesicle-mediated cholesterol transport
cellular response to calcium ion
detection of calcium ion
positive regulation of calcium ion-dependent exocytosis
Cellular Component
GABA-ergic synapse
exocytic vesicle
dense core granule
hippocampal mossy fiber to CA3 synapse
integral component of presynaptic membrane
lysosomal membrane
plasma membrane
axon terminus
lysosome
peroxisome
dendrite
presynaptic membrane
peroxisomal membrane
neuronal cell body
early phagosome
synaptic vesicle
terminal button
synaptic vesicle membrane
phagocytic vesicle membrane
glutamatergic synapse
cytosol
Molecular Function
calmodulin binding
calcium-dependent phospholipid binding
phosphatidylserine binding
clathrin binding
calcium ion binding
phosphatidylinositol-4,5-bisphosphate binding
syntaxin binding
SNARE binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 403
Molecular Weight 45481.99
Theoretical pI 9.272
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 17-37;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q62747
UniProtKB/Swiss-Prot Entry Name SYT7_RAT
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  2. Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871. [PubMed:22673903 ]
  3. Fukuda M, Ogata Y, Saegusa C, Kanno E, Mikoshiba K: Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human. Biochem J. 2002 Jul 1;365(Pt 1):173-80. doi: 10.1042/BJ20011877. [PubMed:12071850 ]
  4. Sugita S, Han W, Butz S, Liu X, Fernandez-Chacon R, Lao Y, Sudhof TC: Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis. Neuron. 2001 May;30(2):459-73. doi: 10.1016/s0896-6273(01)00290-2. [PubMed:11395007 ]
  5. Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Sudhof TC: Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. Nature. 1995 Jun 15;375(6532):594-9. doi: 10.1038/375594a0. [PubMed:7791877 ]
  6. Martinez I, Chakrabarti S, Hellevik T, Morehead J, Fowler K, Andrews NW: Synaptotagmin VII regulates Ca(2+)-dependent exocytosis of lysosomes in fibroblasts. J Cell Biol. 2000 Mar 20;148(6):1141-49. doi: 10.1083/jcb.148.6.1141. [PubMed:10725327 ]
  7. Reddy A, Caler EV, Andrews NW: Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes. Cell. 2001 Jul 27;106(2):157-69. doi: 10.1016/s0092-8674(01)00421-4. [PubMed:11511344 ]
  8. Sugita S, Shin OH, Han W, Lao Y, Sudhof TC: Synaptotagmins form a hierarchy of exocytotic Ca(2+) sensors with distinct Ca(2+) affinities. EMBO J. 2002 Feb 1;21(3):270-80. doi: 10.1093/emboj/21.3.270. [PubMed:11823420 ]
  9. Fukuda M, Kanno E, Satoh M, Saegusa C, Yamamoto A: Synaptotagmin VII is targeted to dense-core vesicles and regulates their Ca2+ -dependent exocytosis in PC12 cells. J Biol Chem. 2004 Dec 10;279(50):52677-84. doi: 10.1074/jbc.M409241200. Epub 2004 Sep 28. [PubMed:15456748 ]
  10. Maximov A, Shin OH, Liu X, Sudhof TC: Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release. J Cell Biol. 2007 Jan 1;176(1):113-24. doi: 10.1083/jcb.200607021. Epub 2006 Dec 26. [PubMed:17190793 ]
  11. Bhalla A, Chicka MC, Chapman ER: Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms. J Biol Chem. 2008 Aug 1;283(31):21799-807. doi: 10.1074/jbc.M709628200. Epub 2008 May 28. [PubMed:18508778 ]