| Identification |
|---|
| HMDB Protein ID
| HMDBP13580 |
| Secondary Accession Numbers
| None |
| Name
| Paired box protein Pax-4 |
| Synonyms
|
Not Available
|
| Gene Name
| PAX4 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity). |
| Pathways
|
- Maturity onset diabetes of the young
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| negative regulation of apoptotic process |
| regulation of cell differentiation |
| anatomical structure development |
| positive regulation of cell differentiation |
| regulation of transcription from RNA polymerase II promoter |
| negative regulation of transcription from RNA polymerase II promoter |
| negative regulation of transcription, DNA-dependent |
| response to cAMP |
| pancreas development |
| circadian rhythm |
| retina development in camera-type eye |
| cell differentiation |
| response to drug |
| Cellular Component |
| nucleus |
| Molecular Function |
| DNA binding |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding |
| double-stranded DNA binding |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| sequence-specific double-stranded DNA binding |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 349 |
| Molecular Weight
| 38484.62 |
| Theoretical pI
| 8.876 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O88436 |
| UniProtKB/Swiss-Prot Entry Name
| PAX4_RAT |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Tokuyama Y, Yagui K, Sakurai K, Hashimoto N, Saito Y, Kanatsuka A: Molecular cloning of rat Pax4: identification of four isoforms in rat insulinoma cells. Biochem Biophys Res Commun. 1998 Jul 9;248(1):153-6. doi: 10.1006/bbrc.1998.8925. [PubMed:9675102 ]
- Campbell SC, Cragg H, Elrick LJ, Macfarlane WM, Shennan KI, Docherty K: Inhibitory effect of pax4 on the human insulin and islet amyloid polypeptide (IAPP) promoters. FEBS Lett. 1999 Dec 10;463(1-2):53-7. doi: 10.1016/s0014-5793(99)01584-7. [PubMed:10601637 ]
|
