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Showing Protein Paired box protein Pax-4 (HMDBP13577)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13577
Secondary Accession Numbers None
Name Paired box protein Pax-4
Synonyms Not Available
Gene Name PAX4
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters.
Pathways
  • Maturity onset diabetes of the young
Reactions Not Available
GO Classification
Biological Process
response to drug
regulation of cell differentiation
anatomical structure development
positive regulation of cell differentiation
regulation of transcription from RNA polymerase II promoter
organ morphogenesis
negative regulation of apoptotic process
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-dependent
response to cAMP
pancreas development
circadian rhythm
retina development in camera-type eye
regulation of transcription, DNA-dependent
cell differentiation
Cellular Component
transcription factor complex
nucleus
Molecular Function
DNA binding
sequence-specific DNA binding transcription factor activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
double-stranded DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
sequence-specific double-stranded DNA binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 349
Molecular Weight 38007.97
Theoretical pI 8.84
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P32115
UniProtKB/Swiss-Prot Entry Name PAX4_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Walther C, Guenet JL, Simon D, Deutsch U, Jostes B, Goulding MD, Plachov D, Balling R, Gruss P: Pax: a murine multigene family of paired box-containing genes. Genomics. 1991 Oct;11(2):424-34. doi: 10.1016/0888-7543(91)90151-4. [PubMed:1685142 ]
  3. Matsushita T, Yamaoka T, Otsuka S, Moritani M, Matsumoto T, Itakura M: Molecular cloning of mouse paired-box-containing gene (Pax)-4 from an islet beta cell line and deduced sequence of human Pax-4. Biochem Biophys Res Commun. 1998 Jan 6;242(1):176-80. doi: 10.1006/bbrc.1997.7935. [PubMed:9439631 ]
  4. Inoue H, Nomiyama J, Nakai K, Matsutani A, Tanizawa Y, Oka Y: Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue. Biochem Biophys Res Commun. 1998 Feb 13;243(2):628-33. doi: 10.1006/bbrc.1998.8144. [PubMed:9480859 ]
  5. Kalousova A, Benes V, Paces J, Paces V, Kozmik Z: DNA binding and transactivating properties of the paired and homeobox protein Pax4. Biochem Biophys Res Commun. 1999 Jun 16;259(3):510-8. doi: 10.1006/bbrc.1999.0809. [PubMed:10364449 ]
  6. Fujitani Y, Kajimoto Y, Yasuda T, Matsuoka TA, Kaneto H, Umayahara Y, Fujita N, Watada H, Miyazaki JI, Yamasaki Y, Hori M: Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a transcriptional repressor in the pancreas. Mol Cell Biol. 1999 Dec;19(12):8281-91. doi: 10.1128/MCB.19.12.8281. [PubMed:10567553 ]
  7. Smith SB, Ee HC, Conners JR, German MS: Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development. Mol Cell Biol. 1999 Dec;19(12):8272-80. doi: 10.1128/MCB.19.12.8272. [PubMed:10567552 ]
  8. Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P: The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature. 1997 Mar 27;386(6623):399-402. doi: 10.1038/386399a0. [PubMed:9121556 ]