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Showing Protein C6 finger domain transcription factor gliZ (HMDBP13573)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13573
Secondary Accession Numbers None
Name C6 finger domain transcription factor gliZ
Synonyms
  1. Gliotoxin production protein Z
Gene Name GLIZ
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transcription factor that regulates gliotoxin production and contributes to virulence (PubMed:15979823, PubMed:17030582, PubMed:20548963, PubMed:21612254).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
pathogenesis
positive regulation of transcription from RNA polymerase II promoter
positive regulation of gliotoxin biosynthetic process
mycotoxin biosynthetic process
regulation of secondary metabolite biosynthetic process
Cellular Component
nucleus
Molecular Function
zinc ion binding
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 489
Molecular Weight 51288.32
Theoretical pI 5.875
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q4WMK0
UniProtKB/Swiss-Prot Entry Name GLIZ_ASPFU
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, Arroyo J, Berriman M, Abe K, Archer DB, Bermejo C, Bennett J, Bowyer P, Chen D, Collins M, Coulsen R, Davies R, Dyer PS, Farman M, Fedorova N, Fedorova N, Feldblyum TV, Fischer R, Fosker N, Fraser A, Garcia JL, Garcia MJ, Goble A, Goldman GH, Gomi K, Griffith-Jones S, Gwilliam R, Haas B, Haas H, Harris D, Horiuchi H, Huang J, Humphray S, Jimenez J, Keller N, Khouri H, Kitamoto K, Kobayashi T, Konzack S, Kulkarni R, Kumagai T, Lafon A, Latge JP, Li W, Lord A, Lu C, Majoros WH, May GS, Miller BL, Mohamoud Y, Molina M, Monod M, Mouyna I, Mulligan S, Murphy L, O'Neil S, Paulsen I, Penalva MA, Pertea M, Price C, Pritchard BL, Quail MA, Rabbinowitsch E, Rawlins N, Rajandream MA, Reichard U, Renauld H, Robson GD, Rodriguez de Cordoba S, Rodriguez-Pena JM, Ronning CM, Rutter S, Salzberg SL, Sanchez M, Sanchez-Ferrero JC, Saunders D, Seeger K, Squares R, Squares S, Takeuchi M, Tekaia F, Turner G, Vazquez de Aldana CR, Weidman J, White O, Woodward J, Yu JH, Fraser C, Galagan JE, Asai K, Machida M, Hall N, Barrell B, Denning DW: Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature. 2005 Dec 22;438(7071):1151-6. doi: 10.1038/nature04332. [PubMed:16372009 ]
  2. Dhingra S, Andes D, Calvo AM: VeA regulates conidiation, gliotoxin production, and protease activity in the opportunistic human pathogen Aspergillus fumigatus. Eukaryot Cell. 2012 Dec;11(12):1531-43. doi: 10.1128/EC.00222-12. Epub 2012 Oct 19. [PubMed:23087369 ]
  3. Gardiner DM, Howlett BJ: Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster of Aspergillus fumigatus. FEMS Microbiol Lett. 2005 Jul 15;248(2):241-8. doi: 10.1016/j.femsle.2005.05.046. [PubMed:15979823 ]
  4. Bok JW, Chung D, Balajee SA, Marr KA, Andes D, Nielsen KF, Frisvad JC, Kirby KA, Keller NP: GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence. Infect Immun. 2006 Dec;74(12):6761-8. doi: 10.1128/IAI.00780-06. Epub 2006 Oct 9. [PubMed:17030582 ]
  5. Shin KS, Kwon NJ, Yu JH: Gbetagamma-mediated growth and developmental control in Aspergillus fumigatus. Curr Genet. 2009 Dec;55(6):631-41. doi: 10.1007/s00294-009-0276-4. Epub 2009 Nov 14. [PubMed:19915845 ]
  6. Forseth RR, Fox EM, Chung D, Howlett BJ, Keller NP, Schroeder FC: Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis. J Am Chem Soc. 2011 Jun 29;133(25):9678-81. doi: 10.1021/ja2029987. Epub 2011 Jun 6. [PubMed:21612254 ]
  7. Sekonyela R, Palmer JM, Bok JW, Jain S, Berthier E, Forseth R, Schroeder F, Keller NP: RsmA regulates Aspergillus fumigatus gliotoxin cluster metabolites including cyclo(L-Phe-L-Ser), a potential new diagnostic marker for invasive aspergillosis. PLoS One. 2013 May 6;8(5):e62591. doi: 10.1371/journal.pone.0062591. Print 2013. [PubMed:23671611 ]
  8. Shin KS, Kim YH, Yu JH: Proteomic analyses reveal the key roles of BrlA and AbaA in biogenesis of gliotoxin in Aspergillus fumigatus. Biochem Biophys Res Commun. 2015 Jul 31;463(3):428-33. doi: 10.1016/j.bbrc.2015.05.090. Epub 2015 May 29. [PubMed:26032501 ]