| Identification |
|---|
| HMDB Protein ID
| HMDBP13558 |
| Secondary Accession Numbers
| None |
| Name
| Alpha-galactosidase |
| Synonyms
|
- Alpha-D-galactoside galactohydrolase
- Melibiase
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Preferentially cleaves alpha-1,3 and alpha-1,4 glycoside linkages. Involved in the hydrolysis of the galactomannan, it splits alpha-linked galactose moieties. It is particularly suitable for the hydrolysis of guar gum to a gum with improved gelling properties. Can cleave terminal alpha-1,3-linked galactose residues responsible for blood group B specificity from the surface of erythrocytes thereby converting these cells serologically to group O. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| carbohydrate metabolic process |
| Molecular Function |
| raffinose alpha-galactosidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 41309.955 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q42656 |
| UniProtKB/Swiss-Prot Entry Name
| AGAL_COFAR |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Zhu A, Goldstein J: Cloning and functional expression of a cDNA encoding coffee bean alpha-galactosidase. Gene. 1994 Mar 25;140(2):227-31. doi: 10.1016/0378-1119(94)90548-7. [PubMed:8144030 ]
- Zhu A, Leng L, Monahan C, Zhang Z, Hurst R, Lenny L, Goldstein J: Characterization of recombinant alpha-galactosidase for use in seroconversion from blood group B to O of human erythrocytes. Arch Biochem Biophys. 1996 Mar 15;327(2):324-9. doi: 10.1006/abbi.1996.0129. [PubMed:8619622 ]
- Kruskall MS, AuBuchon JP, Anthony KY, Herschel L, Pickard C, Biehl R, Horowitz M, Brambilla DJ, Popovsky MA: Transfusion to blood group A and O patients of group B RBCs that have been enzymatically converted to group O. Transfusion. 2000 Nov;40(11):1290-8. doi: 10.1046/j.1537-2995.2000.40111290.x. [PubMed:11099655 ]
- Zhang YP, Gong F, Bao GQ, Gao HW, Ji SP, Tan YX, Li SB, Li LL, Wang YL, Xu H, Xu LJ, Tian SG, Zhang ZX, Lu QS, Qiu Y, Bai JS, Chen JT: B to O erythrocyte conversion by the recombinant alpha-galactosidase. Chin Med J (Engl). 2007 Jul 5;120(13):1145-50. [PubMed:17637242 ]
|
