| Identification |
|---|
| HMDB Protein ID
| HMDBP13557 |
| Secondary Accession Numbers
| None |
| Name
| Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 |
| Synonyms
|
- Forssman glycolipid synthase
|
| Gene Name
| GBGT1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the formation of Forssman glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to GalNAcb-1,3Gala-1,4Galb-1,4GlcCer (Gb4Cer) (PubMed:8855242, PubMed:10506200). Forssman glycolipid (also called Forssman antigen; FG) probably serves for adherence of some pathogens such as E.coli uropathogenic strains (PubMed:10506200). |
| Pathways
|
- Glycosphingolipid biosynthesis - globo and isoglobo series
- protein glycosylation
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| protein glycosylation |
| carbohydrate metabolic process |
| globoside metabolic process |
| Cellular Component |
| integral to membrane |
| Golgi membrane |
| Molecular Function |
| metal ion binding |
| globoside alpha-N-acetylgalactosaminyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 347 |
| Molecular Weight
| 40265.16 |
| Theoretical pI
| 8.899 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q95158 |
| UniProtKB/Swiss-Prot Entry Name
| GBGT1_CANLF |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Xu H, Storch T, Yu M, Elliott SP, Haslam DB: Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial interactions. J Biol Chem. 1999 Oct 8;274(41):29390-8. [PubMed:10506200 ]
- Haslam DB, Baenziger JU: Expression cloning of Forssman glycolipid synthetase: a novel member of the histo-blood group ABO gene family. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10697-702. doi: 10.1073/pnas.93.20.10697. [PubMed:8855242 ]
|
