| Identification |
|---|
| HMDB Protein ID
| HMDBP13529 |
| Secondary Accession Numbers
| None |
| Name
| Ribosomal RNA large subunit methyltransferase Cfr |
| Synonyms
|
- 23S rRNA (adenine(2503)-C(8))-methyltransferase
- 23S rRNA m8A2503 methyltransferase
|
| Gene Name
| CFR |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics, such as chloramphenicol, florfenicol, clindamycin and linezolid. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| response to antibiotic |
| rRNA base methylation |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| metal ion binding |
| 4 iron, 4 sulfur cluster binding |
| rRNA binding |
| rRNA (adenine) methyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 39861.29 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A5HBL2 |
| UniProtKB/Swiss-Prot Entry Name
| CFR_STAAU |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Kehrenberg C, Schwarz S: Distribution of florfenicol resistance genes fexA and cfr among chloramphenicol-resistant Staphylococcus isolates. Antimicrob Agents Chemother. 2006 Apr;50(4):1156-63. doi: 10.1128/AAC.50.4.1156-1163.2006. [PubMed:16569824 ]
- Toh SM, Xiong L, Arias CA, Villegas MV, Lolans K, Quinn J, Mankin AS: Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. Mol Microbiol. 2007 Jun;64(6):1506-14. doi: 10.1111/j.1365-2958.2007.05744.x. [PubMed:17555436 ]
- Mendes RE, Deshpande LM, Castanheira M, DiPersio J, Saubolle MA, Jones RN: First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. Antimicrob Agents Chemother. 2008 Jun;52(6):2244-6. doi: 10.1128/AAC.00231-08. Epub 2008 Apr 7. [PubMed:18391032 ]
- Kehrenberg C, Schwarz S, Jacobsen L, Hansen LH, Vester B: A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Mol Microbiol. 2005 Aug;57(4):1064-73. doi: 10.1111/j.1365-2958.2005.04754.x. [PubMed:16091044 ]
- Grove TL, Radle MI, Krebs C, Booker SJ: Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation. J Am Chem Soc. 2011 Dec 14;133(49):19586-9. doi: 10.1021/ja207327v. Epub 2011 Nov 18. [PubMed:21916495 ]
- Grove TL, Benner JS, Radle MI, Ahlum JH, Landgraf BJ, Krebs C, Booker SJ: A radically different mechanism for S-adenosylmethionine-dependent methyltransferases. Science. 2011 Apr 29;332(6029):604-7. doi: 10.1126/science.1200877. Epub 2011 Mar 17. [PubMed:21415317 ]
|
