| Identification |
|---|
| HMDB Protein ID
| HMDBP13523 |
| Secondary Accession Numbers
| None |
| Name
| Snake venom metalloproteinase bothrojaractivase |
| Synonyms
|
- SVMP
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Prothrombin (F2) activator that is cofactor-independent. Also has fibrinolytic and fibrinogenolytic activity. It degrades the Aalpha-chain and more slowly the Bbeta-chain of fibrin and fibrinogen, while the gamma-chain is only partially and slowly affected. A dose-dependent procoagulant activity is shown in human plasma. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| extracellular region |
| Molecular Function |
| metal ion binding |
| metallopeptidase activity |
| toxin activity |
| peptidase activator activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 7166.235 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0C7A9 |
| UniProtKB/Swiss-Prot Entry Name
| VM1BJ_BOTJA |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Berger M, Pinto AF, Guimaraes JA: Purification and functional characterization of bothrojaractivase, a prothrombin-activating metalloproteinase isolated from Bothrops jararaca snake venom. Toxicon. 2008 Mar 15;51(4):488-501. doi: 10.1016/j.toxicon.2007.09.005. Epub 2008 Feb 11. [PubMed:18262582 ]
|
