| Identification |
|---|
| HMDB Protein ID
| HMDBP13522 |
| Secondary Accession Numbers
| None |
| Name
| Thrombin-like enzyme BpirSP41 |
| Synonyms
|
- SVTLE
- Fibrinogen-clotting enzyme
- Snake venom serine protease
- SVSP
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Snake venom serine protease that interferes with the hemostatic system of the prey. It almost completely degrades both Aalpha (FGA) and Bbeta (FGB) chains of fibrinogen. It presents a higher ability to degrade fibrin clots than BpirSP27. It hydrolyzes chromogenic substrates S-2238 (used for testing thrombin activity), S-2222 (factor Xa), S-2266 (glandular kallikrein and factor XIa), and S-2302 (plasma kallikrein, factor XIa and XIIa). It shows a decrease in the clotting time of human plasma in the presence of increasing doses of the enzyme. Its minimum coagulant dose (MCD) is 20 ug. It promotes platelet aggregation with a maximum of aggregation of 20%, regardless of the concentration increase or the presence of calcium. It also shows 40% inhibition of the hemolytic activity promoted by the complement pathways and possess only a minor role in the induction of edema and pain in rat. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| serine-type endopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 5835.635 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0DL27 |
| UniProtKB/Swiss-Prot Entry Name
| VSP41_BOTPI |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Menaldo DL, Bernardes CP, Santos-Filho NA, Moura Lde A, Fuly AL, Arantes EC, Sampaio SV: Biochemical characterization and comparative analysis of two distinct serine proteases from Bothrops pirajai snake venom. Biochimie. 2012 Dec;94(12):2545-58. doi: 10.1016/j.biochi.2012.07.007. Epub 2012 Jul 17. [PubMed:22819993 ]
- Menaldo DL, Bernardes CP, Pereira JC, Silveira DS, Mamede CC, Stanziola L, Oliveira Fd, Pereira-Crott LS, Faccioli LH, Sampaio SV: Effects of two serine proteases from Bothrops pirajai snake venom on the complement system and the inflammatory response. Int Immunopharmacol. 2013 Apr;15(4):764-71. doi: 10.1016/j.intimp.2013.02.023. Epub 2013 Mar 15. [PubMed:23499645 ]
|
