| Identification |
|---|
| HMDB Protein ID
| HMDBP13509 |
| Secondary Accession Numbers
| None |
| Name
| Hementin |
| Synonyms
|
Not Available
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Metalloprotease with anticoagulant activity. Cleaves fibrinogen Aalpha (FGA), gamma (FGG) and Bbeta (FGB) chains after positions 'Asn-121', 'Lys-160' and 'Pro-102', respectively. Breaks down cross-linked and non-cross-linked fibrin clots. Prevents and reverts platelet aggregation induced by ADP and collagen. Prevents thrombin-induced platelet clotting. Does not affect plasma levels of coagulation factors prothrombin (F2), V (F5), VII (F7), VIII (F8), IX (F9), X (F10), XI (F11), XII (F12), plasma kallikrein (KLKB1) and kininogen-1 (KNG1). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| blood coagulation |
| fibrinolysis |
| Cellular Component |
| extracellular region |
| Molecular Function |
| metallopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q7M3P9 |
| UniProtKB/Swiss-Prot Entry Name
| HTN_HAEGH |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Kirschbaum NE, Budzynski AZ: A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule. J Biol Chem. 1990 Aug 15;265(23):13669-76. [PubMed:2143188 ]
- Swadesh JK, Huang IY, Budzynski AZ: Purification and characterization of hementin, a fibrinogenolytic protease from the leech Haementeria ghilianii. J Chromatogr. 1990 Mar 2;502(2):359-69. doi: 10.1016/s0021-9673(01)89600-x. [PubMed:2187898 ]
- Malinconico SM, Katz JB, Budzynski AZ: Hementin: anticoagulant protease from the salivary gland of the leech Haementeria ghilianii. J Lab Clin Med. 1984 Jan;103(1):44-58. [PubMed:6361187 ]
- Malinconico SM, Katz JB, Budzynski AZ: Fibrinogen degradation by hementin, a fibrinogenolytic anticoagulant from the salivary glands of the leech Haementeria ghilianii. J Lab Clin Med. 1984 Nov;104(5):842-54. [PubMed:6387015 ]
- Sawyer RT, Jones CP, Munro R: The biological function of hementin in the proboscis of the leech Haementeria ghilianii. Blood Coagul Fibrinolysis. 1991 Feb;2(1):153-9. doi: 10.1097/00001721-199102000-00023. [PubMed:1772983 ]
- Electricwala A: Studies on the anticoagulant properties of hementin. Blood Coagul Fibrinolysis. 1992 Oct;3(5):681-2. doi: 10.1097/00001721-199210000-00029. [PubMed:1450340 ]
- Wallis RB, Seale L, Finney S, Sawyer RT, Bennett GM, Ross-Murphy SB: Reduction of plasma clot stability by a novel factor XIIIa inhibitor from the Giant Amazon Leech, Haementeria ghilianii. Blood Coagul Fibrinolysis. 1997 Jul;8(5):291-5. doi: 10.1097/00001721-199707000-00005. [PubMed:9282793 ]
- Seale L, Finney S, Sawyer RT, Wallis RB: Tridegin, a novel peptidic inhibitor of factor XIIIa from the leech, Haementeria ghilianii, enhances fibrinolysis in vitro. Thromb Haemost. 1997 May;77(5):959-63. [PubMed:9184410 ]
|
