Hmdb loader
Identification
HMDB Protein ID HMDBP13487
Secondary Accession Numbers None
Name Prostaglandin reductase 2
Synonyms
  1. PRG-2
  2. 15-oxoprostaglandin 13-reductase
  3. Zinc-binding alcohol dehydrogenase domain-containing protein 1
Gene Name PTGR2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
prostaglandin metabolic process
Cellular Component
cytosol
mitochondrion
Molecular Function
13-prostaglandin reductase activity
15-oxoprostaglandin 13-oxidase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 351
Molecular Weight 38015.12
Theoretical pI 5.41
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8VDQ1
UniProtKB/Swiss-Prot Entry Name PTGR2_MOUSE
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Wu YH, Ko TP, Guo RT, Hu SM, Chuang LM, Wang AH: Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2. Structure. 2008 Nov 12;16(11):1714-23. doi: 10.1016/j.str.2008.09.007. [PubMed:19000823 ]
  4. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  5. Chou WL, Chuang LM, Chou CC, Wang AH, Lawson JA, FitzGerald GA, Chang ZF: Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. J Biol Chem. 2007 Jun 22;282(25):18162-18172. doi: 10.1074/jbc.M702289200. Epub 2007 Apr 21. [PubMed:17449869 ]
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