| Identification |
|---|
| HMDB Protein ID
| HMDBP13445 |
| Secondary Accession Numbers
| None |
| Name
| Trifunctional purine biosynthetic protein adenosine-3 |
| Synonyms
|
Not Available
|
| Gene Name
| GART |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Not Available |
| Pathways
|
- IMP biosynthesis via de novo pathway
- One carbon pool by folate
- Purine metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| purine nucleotide biosynthetic process |
| 'de novo' IMP biosynthetic process |
| adenine biosynthetic process |
| Cellular Component |
| cytosol |
| Molecular Function |
| metal ion binding |
| ATP binding |
| phosphoribosylamine-glycine ligase activity |
| phosphoribosylformylglycinamidine cyclo-ligase activity |
| phosphoribosylglycinamide formyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 1003 |
| Molecular Weight
| 106543.19 |
| Theoretical pI
| 7.583 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P21872 |
| UniProtKB/Swiss-Prot Entry Name
| PUR2_CHICK |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Aimi J, Qiu H, Williams J, Zalkin H, Dixon JE: De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli. Nucleic Acids Res. 1990 Nov 25;18(22):6665-72. [PubMed:2147474 ]
- Aimi J, Badylak J, Williams J, Chen ZD, Zalkin H, Dixon JE: Cloning of a cDNA encoding adenylosuccinate lyase by functional complementation in Escherichia coli. J Biol Chem. 1990 Jun 5;265(16):9011-4. [PubMed:2111814 ]
|
