| Identification |
|---|
| HMDB Protein ID
| HMDBP13432 |
| Secondary Accession Numbers
| None |
| Name
| Probable protein E5 |
| Synonyms
|
Not Available
|
| Gene Name
| E5 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Acts to keep host cells in a proliferation-competent state upon differentiation. Enhances host epidermal growth factor receptor (EGFR) activation after stimulation by EGF by inhibiting EGFR internalization. Induces a redistribution of host caveolin-1 and glycosphingolipid (ganglioside GM1) components of lipid rafts to the plasma membrane. Since GM1s inhibit cytotoxic T-lymphocytes, block immune synapse formation, and enhance proliferative signaling by the EGFR, E5 may enhance immune evasion and cell proliferation via a common mechanism. E5 also alters endosomal pH by interacting with the vacuolar H+-ATPase, which is a proton pump responsible for acidifying cellular organelles. Additionally, E5 prevents transport of the major histocompatibility class I to the cell surface and retains the complex in the Golgi apparatus. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| virus-host interaction |
| suppression by virus of host adaptive immune response |
| suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I |
| negative regulation by symbiont of host apoptotic process |
| Cellular Component |
| integral to membrane |
| host cell plasma membrane |
| host cell endoplasmic reticulum membrane |
| host cell Golgi apparatus |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 83 |
| Molecular Weight
| 9401.48 |
| Theoretical pI
| 8.027 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P06927 |
| UniProtKB/Swiss-Prot Entry Name
| VE5_HPV16 |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Seedorf K, Krammer G, Durst M, Suhai S, Rowekamp WG: Human papillomavirus type 16 DNA sequence. Virology. 1985 Aug;145(1):181-5. doi: 10.1016/0042-6822(85)90214-4. [PubMed:2990099 ]
- Bubb V, McCance DJ, Schlegel R: DNA sequence of the HPV-16 E5 ORF and the structural conservation of its encoded protein. Virology. 1988 Mar;163(1):243-6. doi: 10.1016/0042-6822(88)90259-0. [PubMed:2831662 ]
- Conrad M, Bubb VJ, Schlegel R: The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein. J Virol. 1993 Oct;67(10):6170-8. doi: 10.1128/JVI.67.10.6170-6178.1993. [PubMed:7690419 ]
- Gieswein CE, Sharom FJ, Wildeman AG: Oligomerization of the E5 protein of human papillomavirus type 16 occurs through multiple hydrophobic regions. Virology. 2003 Sep 1;313(2):415-26. doi: 10.1016/s0042-6822(03)00296-4. [PubMed:12954209 ]
- Disbrow GL, Hanover JA, Schlegel R: Endoplasmic reticulum-localized human papillomavirus type 16 E5 protein alters endosomal pH but not trans-Golgi pH. J Virol. 2005 May;79(9):5839-46. doi: 10.1128/JVI.79.9.5839-5846.2005. [PubMed:15827198 ]
- Ashrafi GH, Haghshenas M, Marchetti B, Campo MS: E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domain. Int J Cancer. 2006 Nov 1;119(9):2105-12. doi: 10.1002/ijc.22089. [PubMed:16823848 ]
- Regan JA, Laimins LA: Bap31 is a novel target of the human papillomavirus E5 protein. J Virol. 2008 Oct;82(20):10042-51. doi: 10.1128/JVI.01240-08. Epub 2008 Aug 6. [PubMed:18684816 ]
- Hu L, Ceresa BP: Characterization of the plasma membrane localization and orientation of HPV16 E5 for cell-cell fusion. Virology. 2009 Oct 10;393(1):135-43. doi: 10.1016/j.virol.2009.07.034. Epub 2009 Aug 26. [PubMed:19712955 ]
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