| Identification |
|---|
| HMDB Protein ID
| HMDBP13427 |
| Secondary Accession Numbers
| None |
| Name
| Pre-early 3 receptor internalization and degradation alpha protein |
| Synonyms
|
- Pre-E3-RID-alpha protein
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Prevents infected cell apoptosis induced by the host immune system. Acts by down-regulating a number of cell surface receptors in the tumor necrosis factor (TNF) receptor superfamily, namely FAS, TNFRSF10A/TRAIL receptor 1, and TNFRSF10B/TRAIL receptor 2. Down-regulation of these death receptors protects adenovirus-infected cells from apoptosis induced by the death receptor ligands Fas ligand and TRAIL. RID complex also down-regulates certain tyrosine kinase cell surface receptors, especially the epidermal growth factor receptor (EGFR). RID-mediated Fas and EGFR down-regulation occurs via endocytosis of the receptors into endosomes followed by transport to and degradation within lysosomes. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| integral to membrane |
| host cell membrane |
| host cell endoplasmic reticulum |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 10374.51 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P15133 |
| UniProtKB/Swiss-Prot Entry Name
| E3RDA_ADE02 |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Lichtenstein DL, Toth K, Doronin K, Tollefson AE, Wold WS: Functions and mechanisms of action of the adenovirus E3 proteins. Int Rev Immunol. 2004 Jan-Apr;23(1-2):75-111. doi: 10.1080/08830180490265556. [PubMed:14690856 ]
- Herisse J, Courtois G, Galibert F: Nucleotide sequence of the EcoRI D fragment of adenovirus 2 genome. Nucleic Acids Res. 1980 May 24;8(10):2173-92. doi: 10.1093/nar/8.10.2173. [PubMed:6253880 ]
- Hoffman P, Yaffe MB, Hoffman BL, Yei S, Wold WS, Carlin C: Characterization of the adenovirus E3 protein that down-regulates the epidermal growth factor receptor. Evidence for intermolecular disulfide bonding and plasma membrane localization. J Biol Chem. 1992 Jul 5;267(19):13480-7. [PubMed:1377684 ]
- Krajcsi P, Tollefson AE, Anderson CW, Stewart AR, Carlin CR, Wold WS: The E3-10.4K protein of adenovirus is an integral membrane protein that is partially cleaved between Ala22 and Ala23 and has a Ccyt orientation. Virology. 1992 Mar;187(1):131-44. doi: 10.1016/0042-6822(92)90302-6. [PubMed:1531278 ]
- Shah AH, Cianciola NL, Mills JL, Sonnichsen FD, Carlin C: Adenovirus RIDalpha regulates endosome maturation by mimicking GTP-Rab7. J Cell Biol. 2007 Dec 3;179(5):965-80. doi: 10.1083/jcb.200702187. Epub 2007 Nov 26. [PubMed:18039930 ]
- Cianciola NL, Carlin CR: Adenovirus RID-alpha activates an autonomous cholesterol regulatory mechanism that rescues defects linked to Niemann-Pick disease type C. J Cell Biol. 2009 Nov 16;187(4):537-52. doi: 10.1083/jcb.200903039. [PubMed:19948501 ]
- Windheim M, Hilgendorf A, Burgert HG: Immune evasion by adenovirus E3 proteins: exploitation of intracellular trafficking pathways. Curr Top Microbiol Immunol. 2004;273:29-85. doi: 10.1007/978-3-662-05599-1_2. [PubMed:14674598 ]
|
