| Identification |
|---|
| HMDB Protein ID
| HMDBP13423 |
| Secondary Accession Numbers
| None |
| Name
| Early 3 receptor internalization and degradation beta protein |
| Synonyms
|
- E3 RID-beta protein
- Early E3B 14.5 kDa protein
- E3-14.5k
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Prevents infected cell apoptosis induced by the host immune system. Acts by down-regulating a number of cell surface receptors in the tumor necrosis factor (TNF) receptor superfamily, namely FAS, TNFRSF10A/TRAIL receptor 1, and TNFRSF10B/TRAIL receptor 2. Down-regulation of these death receptors protects adenovirus-infected cells from apoptosis induced by the death receptor ligands Fas ligand and TRAIL. RID complex also down-regulates certain tyrosine kinase cell surface receptors, especially the epidermal growth factor receptor (EGFR). RID-mediated Fas and EGFR down-regulation occurs via endocytosis of the receptors into endosomes followed by transport to and degradation within lysosomes. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| regulation of signal transduction |
| Cellular Component |
| integral to membrane |
| host cell membrane |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 14528.825 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P03250 |
| UniProtKB/Swiss-Prot Entry Name
| E3RDB_ADE02 |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Herisse J, Galibert F: Nucleotide sequence of the EcoRI E fragment of adenovirus 2 genome. Nucleic Acids Res. 1981 Mar 11;9(5):1229-40. doi: 10.1093/nar/9.5.1229. [PubMed:6262722 ]
- Tollefson AE, Krajcsi P, Pursley MH, Gooding LR, Wold WS: A 14,500 MW protein is coded by region E3 of group C human adenoviruses. Virology. 1990 Mar;175(1):19-29. doi: 10.1016/0042-6822(90)90182-q. [PubMed:2309441 ]
- Krajcsi P, Wold WS: The adenovirus E3-14.5K protein which is required for prevention of TNF cytolysis and for down-regulation of the EGF receptor contains phosphoserine. Virology. 1992 Apr;187(2):492-8. doi: 10.1016/0042-6822(92)90451-t. [PubMed:1532104 ]
- Krajcsi P, Tollefson AE, Anderson CW, Wold WS: The adenovirus E3 14.5-kilodalton protein, which is required for down-regulation of the epidermal growth factor receptor and prevention of tumor necrosis factor cytolysis, is an integral membrane protein oriented with its C terminus in the cytoplasm. J Virol. 1992 Mar;66(3):1665-73. doi: 10.1128/JVI.66.3.1665-1673.1992. [PubMed:1531370 ]
- Stewart AR, Tollefson AE, Krajcsi P, Yei SP, Wold WS: The adenovirus E3 10.4K and 14.5K proteins, which function to prevent cytolysis by tumor necrosis factor and to down-regulate the epidermal growth factor receptor, are localized in the plasma membrane. J Virol. 1995 Jan;69(1):172-81. doi: 10.1128/JVI.69.1.172-181.1995. [PubMed:7983708 ]
- Lichtenstein DL, Krajcsi P, Esteban DJ, Tollefson AE, Wold WS: Adenovirus RIDbeta subunit contains a tyrosine residue that is critical for RID-mediated receptor internalization and inhibition of Fas- and TRAIL-induced apoptosis. J Virol. 2002 Nov;76(22):11329-42. doi: 10.1128/jvi.76.22.11329-11342.2002. [PubMed:12388693 ]
- Lichtenstein DL, Toth K, Doronin K, Tollefson AE, Wold WS: Functions and mechanisms of action of the adenovirus E3 proteins. Int Rev Immunol. 2004 Jan-Apr;23(1-2):75-111. doi: 10.1080/08830180490265556. [PubMed:14690856 ]
|
