| Identification |
|---|
| HMDB Protein ID
| HMDBP13409 |
| Secondary Accession Numbers
| None |
| Name
| Serine/threonine-protein kinase US3 |
| Synonyms
|
Not Available
|
| Gene Name
| US3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and inhibition of apoptosis. Phosphorylates UL31 and UL34, two critical regulators of capsid budding from nucleus to endoplasmic reticulum, thereby facilitating virion egress. Modulates and redistributes host components of the nuclear envelope, including LMNA, emerin/EMD and the nuclear matrix protein MATR3. Phosphorylates envelope glycoprotein B (gB), probably to direct it to the cell surface. Promotes virus intracellular spread by restructuring host cell cytoskeleton. Blocks host apoptosis to extend cell survival and allow efficient viral replication. Promotes viral gene expression by phosphorylating host HDAC2 to reduce viral genome silencing (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| modulation by virus of host apoptotic process |
| modulation by virus of host chromatin organization |
| Cellular Component |
| host cell nucleus |
| host cell cytoplasm |
| Molecular Function |
| ATP binding |
| protein serine kinase activity |
| protein threonine kinase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 52677.02 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P13287 |
| UniProtKB/Swiss-Prot Entry Name
| US03_HHV2H |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Leader DP, Purves FC: The herpesvirus protein kinase: a new departure in protein phosphorylation? Trends Biochem Sci. 1988 Jul;13(7):244-6. doi: 10.1016/0968-0004(88)90157-0. [PubMed:2855680 ]
- McGeoch DJ, Moss HW, McNab D, Frame MC: DNA sequence and genetic content of the HindIII l region in the short unique component of the herpes simplex virus type 2 genome: identification of the gene encoding glycoprotein G, and evolutionary comparisons. J Gen Virol. 1987 Jan;68 ( Pt 1):19-38. doi: 10.1099/0022-1317-68-1-19. [PubMed:3027242 ]
- Dolan A, Jamieson FE, Cunningham C, Barnett BC, McGeoch DJ: The genome sequence of herpes simplex virus type 2. J Virol. 1998 Mar;72(3):2010-21. doi: 10.1128/JVI.72.3.2010-2021.1998. [PubMed:9499055 ]
- Finnen RL, Roy BB, Zhang H, Banfield BW: Analysis of filamentous process induction and nuclear localization properties of the HSV-2 serine/threonine kinase Us3. Virology. 2010 Feb 5;397(1):23-33. doi: 10.1016/j.virol.2009.11.012. Epub 2009 Nov 28. [PubMed:19945726 ]
|
