| Identification |
|---|
| HMDB Protein ID
| HMDBP13400 |
| Secondary Accession Numbers
| None |
| Name
| Subtilisin-like serine protease Pen ch 13 |
| Synonyms
|
- Alkaline serine protease
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Serine protease (PubMed:11893850, PubMed:16436150). Hydrolyzes casein, gelatin and human collagen type IV, but not elastin in vitro (PubMed:16436150). Hydrolyzes OCLN of the human lung epithelial cells at 202-Gln-|-Ser-203 and Gln-211-|-Ile-212 (PubMed:16436150). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| proteolysis |
| Cellular Component |
| extracellular space |
| Molecular Function |
| serine-type endopeptidase activity |
| IgE binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 40361.335 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P9WEW3 |
| UniProtKB/Swiss-Prot Entry Name
| PCH13_PENRB |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Chou H, Lai HY, Tam MF, Chou MY, Wang SR, Han SH, Shen HD: cDNA cloning, biological and immunological characterization of the alkaline serine protease major allergen from Penicillium chrysogenum. Int Arch Allergy Immunol. 2002 Jan;127(1):15-26. doi: 10.1159/000048165. [PubMed:11893850 ]
- Shen HD, Lin WL, Tam MF, Wang SR, Tzean SS, Huang MH, Han SH: Characterization of allergens from Penicillium oxalicum and P. notatum by immunoblotting and N-terminal amino acid sequence analysis. Clin Exp Allergy. 1999 May;29(5):642-51. doi: 10.1046/j.1365-2222.1999.00509.x. [PubMed:10231324 ]
- Chou H, Chang CY, Tsai JJ, Tang RB, Lee SS, Wang SR, Peng HJ, Shen HD: The prevalence of IgE antibody reactivity against the alkaline serine protease major allergen of Penicillium chrysogenum increases with the age of asthmatic patients. Ann Allergy Asthma Immunol. 2003 Feb;90(2):248-53. doi: 10.1016/S1081-1206(10)62150-3. [PubMed:12602675 ]
- Tai HY, Tam MF, Chou H, Peng HJ, Su SN, Perng DW, Shen HD: Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells. Allergy. 2006 Mar;61(3):382-8. doi: 10.1111/j.1398-9995.2005.00958.x. [PubMed:16436150 ]
|
