| Identification |
|---|
| HMDB Protein ID
| HMDBP13395 |
| Secondary Accession Numbers
| None |
| Name
| Extracellular cysteine protease |
| Synonyms
|
- Staphopain
|
| Gene Name
| ECPA |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Cysteine protease able to cleave elastin, insulin, myoglobin, fibronectin, fibrinogen, HMW-kininogen, alpha-1-protease inhibitor and alpha-1-antitrypsin. Along with other extracellular proteases may contribute to the colonization and infection of human tissues. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| pathogenesis |
| Cellular Component |
| extracellular region |
| cell wall |
| Molecular Function |
| cysteine-type peptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 174 |
| Molecular Weight
| 19831.945 |
| Theoretical pI
| 8.151 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0C0P9 |
| UniProtKB/Swiss-Prot Entry Name
| ECPA_STAEP |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Dubin G, Chmiel D, Mak P, Rakwalska M, Rzychon M, Dubin A: Molecular cloning and biochemical characterisation of proteases from Staphylococcus epidermidis. Biol Chem. 2001 Nov;382(11):1575-82. doi: 10.1515/BC.2001.192. [PubMed:11767947 ]
- Oleksy A, Golonka E, Banbula A, Szmyd G, Moon J, Kubica M, Greenbaum D, Bogyo M, Foster TJ, Travis J, Potempa J: Growth phase-dependent production of a cell wall-associated elastinolytic cysteine proteinase by Staphylococcus epidermidis. Biol Chem. 2004 Jun;385(6):525-35. doi: 10.1515/BC.2004.062. [PubMed:15255185 ]
|
