| Identification |
|---|
| HMDB Protein ID
| HMDBP13373 |
| Secondary Accession Numbers
| None |
| Name
| Apyrase |
| Synonyms
|
- ATP-diphosphatase
- ATP-diphosphohydrolase
- Adenosine diphosphatase
- ADPase
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Facilitates hematophagy by inhibiting ADP-dependent platelet aggregation in the host. May reduce probing time by facilitating the speed of locating blood. Platelet aggregation was inhibited by 6% when 0.4 uM recombinant apyrase was added and by 9.5% when the concentration of recombinant apyrase was 0.8 uM. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| nucleotide catabolic process |
| Cellular Component |
| extracellular region |
| Molecular Function |
| metal ion binding |
| ATP binding |
| hydrolase activity, acting on ester bonds |
| 8-oxo-dGTP phosphohydrolase activity |
| dATP phosphohydrolase activity |
| dCTP phosphohydrolase activity |
| dGTP phosphohydrolase activity |
| dTTP phosphohydrolase activity |
| dUTP phosphohydrolase activity |
| GTP phosphohydrolase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 62750.425 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| E0D877 |
| UniProtKB/Swiss-Prot Entry Name
| APY_AEDAL |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Dong F, Fu Y, Li X, Jiang J, Sun J, Cheng X: Cloning, expression, and characterization of salivary apyrase from Aedes albopictus. Parasitol Res. 2012 Feb;110(2):931-7. doi: 10.1007/s00436-011-2579-x. Epub 2011 Aug 14. [PubMed:21842387 ]
- Arca B, Lombardo F, Francischetti IM, Pham VM, Mestres-Simon M, Andersen JF, Ribeiro JM: An insight into the sialome of the adult female mosquito Aedes albopictus. Insect Biochem Mol Biol. 2007 Feb;37(2):107-27. doi: 10.1016/j.ibmb.2006.10.007. Epub 2006 Nov 7. [PubMed:17244540 ]
|
