| Identification |
|---|
| HMDB Protein ID
| HMDBP13362 |
| Secondary Accession Numbers
| None |
| Name
| Mu-theraphotoxin-Ae1a |
| Synonyms
|
- Mu-TRTX-Ae1a
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Insecticidal toxin that acts, at least partially, by inhibiting insect voltage-gated sodium (NaV) channels of several insect species. The toxin binds to the voltage sensor in NaV channel domain II and inhibits channel opening by shifting the threshold for channel activation to more positive voltages. The toxin binding is sensitive to residues in the S1-S2 loop of the domain II voltage sensor. In vivo, the recombinant toxin causes paralysis and/or death to two dipteran species (Lucilia cuprina and Drosophila melanogaster). In contrast, the toxin does not show paralytic or lethal effect on the cotton bollworm Helicoverpa armigera and the triatomine bug Rhodinius prolixus. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| pathogenesis |
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| ion channel inhibitor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 4267.79 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0DPG5 |
| UniProtKB/Swiss-Prot Entry Name
| TX1A_AUGEZ |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Herzig V, Ikonomopoulou M, Smith JJ, Dziemborowicz S, Gilchrist J, Kuhn-Nentwig L, Rezende FO, Moreira LA, Nicholson GM, Bosmans F, King GF: Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami. Sci Rep. 2016 Jul 7;6:29538. doi: 10.1038/srep29538. [PubMed:27383378 ]
|
