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Showing Protein Pyridoxal 5'-phosphate synthase subunit Pdx2 (HMDBP13308)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13308
Secondary Accession Numbers None
Name Pyridoxal 5'-phosphate synthase subunit Pdx2
Synonyms
  1. Pyridoxal 5'-phosphate synthase glutaminase subunit
Gene Name PDX2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of Pdx1.
Pathways
  • Biosynthesis of cofactors
  • pyridoxal 5'-phosphate biosynthesis
  • Vitamin B6 metabolism
Reactions Not Available
GO Classification
Biological Process
glutamine metabolic process
pyridoxal phosphate biosynthetic process
response to singlet oxygen
vitamin B6 biosynthetic process
pyridoxine metabolic process
Cellular Component
cytosol
glutaminase complex
Molecular Function
glutaminase activity
pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 219
Molecular Weight 24562.95
Theoretical pI 6.906
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8IIK4
UniProtKB/Swiss-Prot Entry Name PDX2_PLAF7
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. doi: 10.1038/nature01097. [PubMed:12368864 ]
  2. Gengenbacher M, Fitzpatrick TB, Raschle T, Flicker K, Sinning I, Muller S, Macheroux P, Tews I, Kappes B: Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: biochemical and structural insights. J Biol Chem. 2006 Feb 10;281(6):3633-41. doi: 10.1074/jbc.M508696200. Epub 2005 Dec 8. [PubMed:16339145 ]
  3. Muller IB, Knockel J, Groves MR, Jordanova R, Ealick SE, Walter RD, Wrenger C: The assembly of the plasmodial PLP synthase complex follows a defined course. PLoS One. 2008 Mar 19;3(3):e1815. doi: 10.1371/journal.pone.0001815. [PubMed:18350152 ]
  4. Guedez G, Hipp K, Windeisen V, Derrer B, Gengenbacher M, Bottcher B, Sinning I, Kappes B, Tews I: Assembly of the eukaryotic PLP-synthase complex from Plasmodium and activation of the Pdx1 enzyme. Structure. 2012 Jan 11;20(1):172-84. doi: 10.1016/j.str.2011.11.015. [PubMed:22244765 ]
  5. Wrenger C, Eschbach ML, Muller IB, Warnecke D, Walter RD: Analysis of the vitamin B6 biosynthesis pathway in the human malaria parasite Plasmodium falciparum. J Biol Chem. 2005 Feb 18;280(7):5242-8. doi: 10.1074/jbc.M412475200. Epub 2004 Dec 7. [PubMed:15590634 ]