Hmdb loader
Identification
HMDB Protein ID HMDBP13277
Secondary Accession Numbers None
Name Beta-enolase
Synonyms
  1. 2-phospho-D-glycerate hydro-lyase
  2. Enolase 3
  3. Muscle-specific enolase
  4. Skeletal muscle enolase
  5. MSE
Gene Name ENO3
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Appears to have a function in striated muscle development and regeneration.
Pathways
  • Biosynthesis of amino acids
  • Carbon metabolism
  • glycolysis
  • Glycolysis / Gluconeogenesis
  • HIF-1 signaling pathway
  • RNA degradation
Reactions Not Available
GO Classification
Biological Process
response to drug
aging
glycolysis
skeletal muscle tissue regeneration
regulation of vacuole fusion, non-autophagic
Cellular Component
cytosol
plasma membrane
membrane
phosphopyruvate hydratase complex
Molecular Function
magnesium ion binding
identical protein binding
phosphopyruvate hydratase activity
protein-containing complex binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 434
Molecular Weight 47024.495
Theoretical pI 7.179
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P21550
UniProtKB/Swiss-Prot Entry Name ENOB_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y: The transcriptional landscape of the mammalian genome. Science. 2005 Sep 2;309(5740):1559-63. [PubMed:16141072 ]
  3. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  4. Merkulova T, Lucas M, Jabet C, Lamande N, Rouzeau JD, Gros F, Lazar M, Keller A: Biochemical characterization of the mouse muscle-specific enolase: developmental changes in electrophoretic variants and selective binding to other proteins. Biochem J. 1997 May 1;323 ( Pt 3):791-800. doi: 10.1042/bj3230791. [PubMed:9169614 ]
  5. Keller A, Demeurie J, Merkulova T, Geraud G, Cywiner-Golenzer C, Lucas M, Chatelet FP: Fibre-type distribution and subcellular localisation of alpha and beta enolase in mouse striated muscle. Biol Cell. 2000 Oct;92(7):527-35. doi: 10.1016/s0248-4900(00)01103-5. [PubMed:11229603 ]
  6. Nakamura N, Dai Q, Williams J, Goulding EH, Willis WD, Brown PR, Eddy EM: Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility. Biol Reprod. 2013 Apr 11;88(4):90. doi: 10.1095/biolreprod.112.107128. Print 2013 Apr. [PubMed:23446454 ]
  7. Peterson CA, Cho M, Rastinejad F, Blau HM: Beta-enolase is a marker of human myoblast heterogeneity prior to differentiation. Dev Biol. 1992 Jun;151(2):626-9. doi: 10.1016/0012-1606(92)90201-q. [PubMed:1339335 ]
  8. Lamande N, Mazo AM, Lucas M, Montarras D, Pinset C, Gros F, Legault-Demare L, Lazar M: Murine muscle-specific enolase: cDNA cloning, sequence, and developmental expression. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4445-9. doi: 10.1073/pnas.86.12.4445. [PubMed:2734297 ]
  9. Keller A, Ott MO, Lamande N, Lucas M, Gros F, Buckingham M, Lazar M: Activation of the gene encoding the glycolytic enzyme beta-enolase during early myogenesis precedes an increased expression during fetal muscle development. Mech Dev. 1992 Jul;38(1):41-54. doi: 10.1016/0925-4773(92)90037-k. [PubMed:1525038 ]
  10. Keller A, Rouzeau JD, Farhadian F, Wisnewsky C, Marotte F, Lamande N, Samuel JL, Schwartz K, Lazar M, Lucas M: Differential expression of alpha- and beta-enolase genes during rat heart development and hypertrophy. Am J Physiol. 1995 Dec;269(6 Pt 2):H1843-51. doi: 10.1152/ajpheart.1995.269.6.H1843. [PubMed:8594891 ]
  11. Merkulova T, Dehaupas M, Nevers MC, Creminon C, Alameddine H, Keller A: Differential modulation of alpha, beta and gamma enolase isoforms in regenerating mouse skeletal muscle. Eur J Biochem. 2000 Jun;267(12):3735-43. doi: 10.1046/j.1432-1327.2000.01408.x. [PubMed:10848992 ]