| Identification |
|---|
| HMDB Protein ID
| HMDBP13272 |
| Secondary Accession Numbers
| None |
| Name
| Hexokinase-2 |
| Synonyms
|
- Cytoplasmic antigenic protein 3
- Hexokinase PII
- Hexokinase-B
|
| Gene Name
| HXK2 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. |
| Pathways
|
- Amino sugar and nucleotide sugar metabolism
- Biosynthesis of secondary metabolites
- Carbon metabolism
- Fructose and mannose metabolism
- Galactose metabolism
- glycolysis
- Glycolysis / Gluconeogenesis
- hexose metabolism
- Starch and sucrose metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| glycolysis |
| glucose 6-phosphate metabolic process |
| hexose metabolic process |
| cellular glucose homeostasis |
| Cellular Component |
| cytosol |
| mitochondrion |
| Molecular Function |
| ATP binding |
| glucose binding |
| fructokinase activity |
| glucokinase activity |
| mannokinase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 484 |
| Molecular Weight
| 53415.975 |
| Theoretical pI
| 5.558 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P83776 |
| UniProtKB/Swiss-Prot Entry Name
| HXKB_CANAL |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S: The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34. doi: 10.1073/pnas.0401648101. Epub 2004 May 3. [PubMed:15123810 ]
- van het Hoog M, Rast TJ, Martchenko M, Grindle S, Dignard D, Hogues H, Cuomo C, Berriman M, Scherer S, Magee BB, Whiteway M, Chibana H, Nantel A, Magee PT: Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes. Genome Biol. 2007;8(4):R52. doi: 10.1186/gb-2007-8-4-r52. [PubMed:17419877 ]
- Muzzey D, Schwartz K, Weissman JS, Sherlock G: Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Genome Biol. 2013;14(9):R97. doi: 10.1186/gb-2013-14-9-r97. [PubMed:24025428 ]
- Pitarch A, Abian J, Carrascal M, Sanchez M, Nombela C, Gil C: Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies. Proteomics. 2004 Oct;4(10):3084-106. doi: 10.1002/pmic.200400903. [PubMed:15378761 ]
|
