| Identification |
|---|
| HMDB Protein ID
| HMDBP13250 |
| Secondary Accession Numbers
| None |
| Name
| Glyceraldehyde-3-phosphate dehydrogenase |
| Synonyms
|
- GAPDH
- NAD-dependent glyceraldehyde-3-phosphate dehydrogenase
|
| Gene Name
| GAP |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. Also binds human plasminogen. |
| Pathways
|
- Biosynthesis of amino acids
- Biosynthesis of secondary metabolites
- Carbon metabolism
- glycolysis
- Glycolysis / Gluconeogenesis
- Microbial metabolism in diverse environments
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| glycolysis |
| glucose metabolic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| NAD binding |
| NADP binding |
| glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 336 |
| Molecular Weight
| 35972.525 |
| Theoretical pI
| 5.559 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0DB19 |
| UniProtKB/Swiss-Prot Entry Name
| G3P_STRPQ |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Nakagawa I, Kurokawa K, Yamashita A, Nakata M, Tomiyasu Y, Okahashi N, Kawabata S, Yamazaki K, Shiba T, Yasunaga T, Hayashi H, Hattori M, Hamada S: Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution. Genome Res. 2003 Jun;13(6A):1042-55. doi: 10.1101/gr.1096703. [PubMed:12799345 ]
|
